Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Org Lett. 2022 Jan 14;24(1):441-445. doi: 10.1021/acs.orglett.1c04135. Epub 2021 Dec 14.
Robust air-stable cyclometalated π-allyliridium ,-benzoates modified by ()-tol-BINAP catalyze the reaction of secondary aliphatic amines with racemic alkyl-substituted allylic acetates to furnish products of allylic amination with high levels of enantioselectivity. Complete branched regioselectivities were observed despite the formation of more highly substituted C-N bonds.
()-托-BINAP 改性的稳定空气的环金属化的 π-烯丙基铱、-苯甲酸酯催化仲脂肪族胺与外消旋烷基取代的烯丙基乙酸酯的反应,以高对映选择性得到烯丙基胺化产物。尽管形成了取代程度更高的 C-N 键,但观察到完全支化的区域选择性。