Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.
作者信息
Ratcliffe Peter J
机构信息
Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK, and director of clinical research, Francis Crick Institute, London, UK
出版信息
Clin Med (Lond). 2022 Jan;22(1):23-33. doi: 10.7861/clinmed.ed.22.1.harv. Epub 2021 Dec 17.
Abstract
摘要
相似文献
1
Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine.
Clin Med (Lond). 2022 Jan;22(1):23-33. doi: 10.7861/clinmed.ed.22.1.harv. Epub 2021 Dec 17.
2
Cellular oxygen sensing need in CNS function: physiological and pathological implications.
J Exp Biol. 2004 Aug;207(Pt 18):3171-88. doi: 10.1242/jeb.01075.
3
Harveian Oration 2015: Medicine, science and values - with hindsight and foresight.
Clin Med (Lond). 2016 Apr;16(2):164-70. doi: 10.7861/clinmedicine.16-2-164.
4
Harveian Oration 2017: Triumphs and challenges in a world shaped by medicine.
Clin Med (Lond). 2017 Dec;17(6):537-544. doi: 10.7861/clinmedicine.17-6-537.
5
Harveian Oration 2008.
Clin Med (Lond). 2009 Apr;9(2):196; author reply 196. doi: 10.7861/clinmedicine.9-2-196.
6
Harvey and his contemporaries; the Harveian Oration of 1957.
Lancet. 1957 Oct 26;273(7000):811-9. doi: 10.1016/s0140-6736(57)91486-1.
7
The marvel of the lung and human responsibility--'a great contempt of God's good gifts'? The Harveian Oration of 1994.
J R Coll Physicians Lond. 1994 Nov-Dec;28(6):530-7.
8
The Harveian Oration on the Debt of Medicine to the Experimental Method of Harvey.
Br Med J. 1926 Oct 23;2(3433):719-23. doi: 10.1136/bmj.2.3433.719.
9
Extracts from the Harveian Oration on the Progress of Medicine and Sanitation.
Br Med J. 1889 Oct 26;2(1504):913-6. doi: 10.1136/bmj.2.1504.913.
10
The Harveian Oration on Harvey in Ancient and Modern Medicine.
Br Med J. 1891 Oct 24;2(1608):883-7. doi: 10.1136/bmj.2.1608.883.
引用本文的文献
1
Making sense of oxygen sensing.
EMBO J. 2025 Aug 1. doi: 10.1038/s44318-025-00513-1.
2
Do you need a weatherman to know which way the wind blows?
Clin Med (Lond). 2022 Jan;22(1):1. doi: 10.7861/clinmed.ed.22.1.1.
本文引用的文献
1
Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension.
Eur Respir J. 2021 Mar 4;57(3). doi: 10.1183/13993003.02061-2019. Print 2021 Mar.
2
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
J Clin Invest. 2020 May 1;130(5):2237-2251. doi: 10.1172/JCI133194.
3
Roxadustat and Anemia of Chronic Kidney Disease.
N Engl J Med. 2019 Sep 12;381(11):1070-1072. doi: 10.1056/NEJMe1908978. Epub 2019 Jul 24.
4
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants.
Science. 2019 Jul 5;365(6448):65-69. doi: 10.1126/science.aaw0112.
5
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
J Clin Invest. 2019 Jun 4;129(9):3640-3656. doi: 10.1172/JCI124099.
6
Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis.
Clin Kidney J. 2019 Feb;12(1):139-148. doi: 10.1093/ckj/sfy014. Epub 2018 Mar 19.
7
N-degron and C-degron pathways of protein degradation.
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):358-366. doi: 10.1073/pnas.1816596116.
8
Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin.
EMBO Rep. 2019 Jan;20(1). doi: 10.15252/embr.201846401. Epub 2018 Nov 14.
9
PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
J Physiol. 2018 Jun 19;596(18):4393-412. doi: 10.1113/JP275996.
10
Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.
J Clin Oncol. 2018 Mar 20;36(9):867-874. doi: 10.1200/JCO.2017.74.2627. Epub 2017 Dec 19.
Zotero 插件