J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):860-861. doi: 10.1016/j.jaac.2021.12.002. Epub 2021 Dec 15.
For many years, the median age of diagnosis has been the most widely used metric for evaluating changes in the early diagnosis of autism. The logic appears simple: if health and educational systems improve their ability to diagnose autism at early ages, then it would seem that the median age should fall. However, despite decades of efforts in the United States to improve the early identification, the median age of diagnosis has hardly budged. But simple logic can be deceptive. In a watershed analysis of data from the Autism and Developmental Disabilities Monitoring Network-the most prominent study of autism prevalence in the United States-Shaw and colleagues apply different metrics to existing data to yield novel findings. Citing earlier methodological work published in this journal and others, the authors report what they refer to as the "simple median age of diagnosis" (ie, the median age at the earliest recorded autism spectrum disorder diagnosis or special educational eligibility before 8 years of age) alongside 2 alternative metrics: (1) "median age at identification"-similar to the "simple median" except that it also includes children who meet case definitions for autism but are not yet identified by 8 years of age (ie, they do not have a recorded diagnosis or record of special education eligibility); and (2) cumulative incidence of autism by 4 years of age-ie, the ratio of the number of children diagnosed by 48 months of age divided by the total number of children in the population. Results have tremendous implications both for research and policy.
多年来,诊断中位年龄一直是评估自闭症早期诊断变化的最常用指标。逻辑似乎很简单:如果健康和教育系统提高了在早期诊断自闭症的能力,那么中位数年龄应该会下降。然而,尽管美国数十年来一直努力提高早期识别能力,但诊断的中位年龄几乎没有变化。但简单的逻辑可能具有欺骗性。在对自闭症和发育障碍监测网络(美国最著名的自闭症流行率研究)的数据进行的分水岭分析中,Shaw 及其同事应用不同的指标来分析现有数据,得出了新的发现。作者引用了早些时候在该杂志和其他杂志上发表的早期方法学工作,报告了他们所谓的“简单诊断中位年龄”(即最早记录的自闭症谱系障碍诊断或 8 岁前特殊教育资格的中位年龄),以及另外两个替代指标:(1)“识别中位年龄”-类似于“简单中位”,但它还包括符合自闭症病例定义但到 8 岁尚未被识别的儿童(即他们没有记录的诊断或特殊教育资格记录);以及(2)4 岁时自闭症的累积发病率-即 48 个月时被诊断出的儿童人数与人口中儿童总数的比例。这些结果对研究和政策都具有巨大的影响。