Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia.
Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia.
Mediators Inflamm. 2021 Dec 11;2021:6609143. doi: 10.1155/2021/6609143. eCollection 2021.
The most prevalent cause of mortality and morbidity worldwide is acute coronary syndrome (ACS) and its consequences. Exposure to particulate matter (PM) from air pollution has been shown to impair both. Various plausible pathogenic mechanisms have been identified, including microRNAs (miRNAs), an epigenetic regulator for gene expression. Endogenous miRNAs, average 22-nucleotide RNAs (ribonucleic acid), regulate gene expression through mRNA cleavage or translation repression and can influence proinflammatory gene expression posttranscriptionally. However, little is known about miRNA responses to fine PM (PM, PM, ultrafine particles, black carbon, and polycyclic aromatic hydrocarbon) from air pollution and their potential contribution to cardiovascular consequences, including systemic inflammation regulation. For the past decades, microRNAs (miRNAs) have emerged as novel, prospective diagnostic and prognostic biomarkers in various illnesses, including ACS. We wanted to outline some of the most important studies in the field and address the possible utility of miRNAs in regulating particulate matter-induced ACS (PMIA) on inflammatory factors in this review.
全球范围内，死亡率和发病率最高的原因是急性冠状动脉综合征（ACS）及其后果。暴露于空气污染中的颗粒物（PM）已被证明会损害这两者。已经确定了各种合理的发病机制，包括 microRNAs（miRNAs），这是一种用于基因表达的表观遗传调节剂。内源性 miRNAs 是平均 22 个核苷酸的 RNA（核糖核酸），通过 mRNA 切割或翻译抑制来调节基因表达，并可以在后转录水平上影响促炎基因的表达。然而，对于 miRNA 对来自空气污染的细颗粒物（PM、PM、超细颗粒、黑碳和多环芳烃）的反应及其对心血管后果（包括全身炎症调节）的潜在贡献，人们知之甚少。在过去的几十年中，microRNAs（miRNAs）已成为各种疾病（包括 ACS）的新型、有前途的诊断和预后生物标志物。我们想在这篇综述中概述该领域的一些重要研究，并探讨 miRNA 在调节颗粒物诱导的 ACS（PMIA）对炎症因子的可能作用。
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