Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam, The Netherlands.
Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands; Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Biologics Laboratory, Sanquin Diagnostic Services, Amsterdam, The Netherlands.
Mult Scler. 2022 Feb;28(2):323-326. doi: 10.1177/13524585211052168. Epub 2021 Dec 21.
In women with very active multiple sclerosis (MS), natalizumab can be continued during pregnancy to prevent rebound disease activity. Our aim was to evaluate changes in serum natalizumab trough concentrations during pregnancy. Blood samples of 3 patients were collected before, during, and after pregnancy. Natalizumab trough concentrations gradually decreased during pregnancy. The patient with the lowest trough concentrations during the third trimester was treated with extended interval dosing (EID). After delivery, natalizumab concentrations increased to similar levels as before pregnancy. All patients remained clinically and radiologically stable. MS neurologists should be aware of decreasing natalizumab concentrations during pregnancy, especially in patients with low initial trough concentrations and patients with EID.
在多发性硬化症（MS）非常活跃的女性中，那他珠单抗可在怀孕期间继续使用以预防疾病活动反弹。我们的目的是评估怀孕期间血清那他珠单抗谷浓度的变化。采集了 3 名患者怀孕前、怀孕中和怀孕后的血样。那他珠单抗谷浓度在怀孕期间逐渐下降。在孕晚期谷浓度最低的患者接受了延长间隔给药（EID）治疗。分娩后，那他珠单抗浓度增加至与怀孕前相似的水平。所有患者的临床和放射学均保持稳定。MS 神经科医生应注意到怀孕期间那他珠单抗浓度降低，特别是在初始谷浓度较低的患者和接受 EID 的患者中。
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