脑干胶质瘤的实验性小鼠模型
Experimental murine models of brainstem gliomas.
作者信息
Ni Shuting, Chen Rujing, Hu Kaili
机构信息
Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
出版信息
Drug Discov Today. 2022 May;27(5):1218-1235. doi: 10.1016/j.drudis.2021.12.016. Epub 2021 Dec 23.
As an intractable central nervous system (CNS) tumor, brainstem glioma (BG) is one of the leading causes of pediatric death by brain tumors. Owing to the risk of surgical resection and the little improvement in survival time after radiotherapy and chemotherapy, there is an urgent need to find reliable model systems to better understand the regional pathogenesis of the brainstem and improve treatment strategies. In this review, we outline the evolution of BG murine models, and discuss both their advantages and limitations in drug discovery.
作为一种难以治疗的中枢神经系统（CNS）肿瘤，脑干胶质瘤（BG）是儿童脑肿瘤致死的主要原因之一。由于手术切除存在风险，且放疗和化疗后生存时间改善甚微，因此迫切需要找到可靠的模型系统，以更好地了解脑干的区域发病机制并改进治疗策略。在本综述中，我们概述了BG小鼠模型的发展历程，并讨论了它们在药物研发中的优缺点。
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