催乳素、糖尿病与认知障碍的关联：文献综述
Associations between Prolactin, Diabetes, and Cognitive Impairment: A Literature Review.
机构信息
Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea,
Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
出版信息
Neuroendocrinology. 2022;112(9):856-873. doi: 10.1159/000521653. Epub 2021 Dec 28.
BACKGROUND
Converging evidence indicates prolactin (PRL) and diabetes play an important role in the pathophysiology of cognitive impairment. However, little is known about the mechanisms responsible for the effects of PRL and diabetes on cognitive impairment.
SUMMARY
We summarize and review the available literature and current knowledge of the association between PRL and diabetes on aspects of cognitive impairment.
KEY MESSAGES
The phosphatidylinositol 3-kinase/protein kinase B pathway is central to the molecular mechanisms underlying how PRL and diabetes interact in cognitive impairment. Further work is needed to identify the interaction between PRL and diabetes, especially in the molecular aspects of cognitive impairment, which can suggest novel strategies for cognitive dysfunction treatment.
背景
越来越多的证据表明，催乳素（PRL）和糖尿病在认知障碍的病理生理学中起着重要作用。然而，对于催乳素和糖尿病影响认知障碍的机制知之甚少。
总结
我们总结和回顾了现有的文献和目前关于催乳素和糖尿病与认知障碍各方面关系的知识。
关键信息
磷脂酰肌醇 3-激酶/蛋白激酶 B 途径是催乳素和糖尿病在认知障碍中相互作用的分子机制的核心。需要进一步研究以确定催乳素和糖尿病之间的相互作用，特别是在认知障碍的分子方面，这可以为认知功能障碍的治疗提供新的策略。
Zotero 插件