Li R, Luo S Y, Zuo Z G, Yu Z, Chen W N, Ye Y X, Xia M
Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Department of Prevention and Health, Dongguan Chashan Community Health Service Center, Dongguan 523381, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Dec 6;55(12):1449-1455. doi: 10.3760/cma.j.cn112150-20210603-00540.
To analyze the association between serum uric acid to creatinine ratio (SUA/Cr) and metabolic syndrome among community residents in Chashan town, Dongguan city. Participants were from the prospective cohort study of chronic diseases in natural populations in South China conducted in Chashan town, Dongguan city from 2018 to 2019. A total of 11 334 participants with complete data were included by using convenient sampling method. Demographic characteristics, lifestyle and health status were collected through questionnaire and physical examination. The venous blood of the subjects was collected to detect the levels of serum uric acid, creatinine and blood lipid. All participants were divided into four groups (Q1-Q4) according to the quartile of SUA/Cr level. The relationship between SUA/Cr and metabolic syndrome and its components (abdominal obesity, high triglyceride, low level of high density lipoprotein cholesterol, hypertension and abnormal glucose metabolism) were analyzed by using logistic regression model. The mean age of 11 334 participants was (49.52±10.02) years. Male participants accounted for 44.2% (5 015/11 334). The prevalence of metabolic syndrome was 31.2% (3 532/11 334), and the level of SUA/Cr was 5.17±1.53. The prevalence of metabolic syndrome in group Q1-Q4 was 22.3% (631/2 834), 26.5% (752/2 833), 34.9% (988/2 833) and 41.0% (1 161/2 834), respectively. After adjusting for relevant confounding factors, the result of logistic regression model showed that compared with group Q1, the risk of metabolic syndrome in group Q2-Q4 was significantly higher, with (95%) values about 1.41 (1.23-1.60), 2.19 (1.93-2.49) and 3.01 (2.65-3.42) respectively. The risk of each component of metabolic syndrome in group Q2-Q4 was higher (<0.001). The SUA/Cr level of participants with normal uric acid level was significantly positively correlated with metabolic syndrome. The risk of metabolic syndrome increased with the increase of SUA/Cr level, but there was the same trend without significant differences in patients with hyperuricemia (=0.008). There is a positive correlation between SUA/Cr level and the risk of metabolic syndrome among community residents in Chashan town, Dongguan city.
分析东莞市茶山镇社区居民血清尿酸与肌酐比值（SUA/Cr）与代谢综合征之间的关联。研究对象来自于2018年至2019年在东莞市茶山镇开展的中国南方自然人群慢性病前瞻性队列研究。采用方便抽样法，共纳入11334例数据完整的参与者。通过问卷调查和体格检查收集人口统计学特征、生活方式和健康状况。采集受试者静脉血检测血清尿酸、肌酐和血脂水平。所有参与者根据SUA/Cr水平的四分位数分为四组（Q1-Q4）。采用logistic回归模型分析SUA/Cr与代谢综合征及其组分（腹型肥胖、高甘油三酯、低高密度脂蛋白胆固醇水平、高血压和糖代谢异常）之间的关系。11334例参与者的平均年龄为（49.52±10.02）岁。男性参与者占44.2%（5015/11334）。代谢综合征患病率为31.2%（3532/11334），SUA/Cr水平为5.17±1.53。Q1-Q4组代谢综合征患病率分别为22.3%（631/2834）、26.5%（752/2833）、34.9%（988/2833）和41.0%（1161/2834）。校正相关混杂因素后，logistic回归模型结果显示，与Q1组相比，Q2-Q4组代谢综合征风险显著更高，（95%）值分别约为1.41（1.23-1.60）、2.19（1.93-2.49）和3.01（2.65-3.42）。Q2-Q4组代谢综合征各组分风险更高（<0.001）。尿酸水平正常的参与者的SUA/Cr水平与代谢综合征显著正相关。代谢综合征风险随SUA/Cr水平升高而增加，但高尿酸血症患者也有相同趋势，差异无统计学意义（=0.008）。东莞市茶山镇社区居民SUA/Cr水平与代谢综合征风险之间存在正相关。
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