异常的音猬因子信号通路在癌症和发育异常中的作用。

Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies.

作者信息

Patel Trupti N, Dhanyamraju Pavan Kumar

机构信息

School of Biosciences and Technology, Vellore Institute of Technology, Vellore Campus, Vellore, Tamil Nadu 632014, India.

Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA.

出版信息

J Biomed Res. 2021 Dec 15;36(1):1-9. doi: 10.7555/JBR.35.20210139.

DOI:10.7555/JBR.35.20210139

PMID:34963676

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8894283/

Abstract

Development is a sophisticated process maintained by various signal transduction pathways, including the Hedgehog (Hh) pathway. Several important functions are executed by the Hh signaling cascade such as organogenesis, tissue regeneration, and tissue homeostasis, among various others. Considering the multiple functions carried out by this pathway, any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers. In the present review article, we explored a wide range of diseases caused by aberrant Hh signaling, including developmental defects and cancers. Finally, we concluded this mini-review with various treatment strategies for Hh-induced diseases.

摘要

发育是一个由多种信号转导通路维持的复杂过程，包括刺猬（Hh）通路。Hh信号级联执行多种重要功能，如器官发生、组织再生和组织稳态等。鉴于该通路执行的多种功能，任何导致Hh信号异常的突变除了引发癌症外，还可能导致无数发育异常。在本综述文章中，我们探讨了由异常Hh信号引起的多种疾病，包括发育缺陷和癌症。最后，我们总结了针对Hh诱导疾病的各种治疗策略，结束了这篇小型综述。