Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China.
School of Public Health, Fudan University, Shanghai 200437, China.
Environ Sci Technol. 2022 Jun 7;56(11):7203-7213. doi: 10.1021/acs.est.1c03754. Epub 2021 Dec 29.
Exposure to fine particulate matter (PM) is associated with various adverse health effects, such as respiratory and cardiovascular diseases. This study aimed to evaluate the association of PM with neural damage biomarkers. A total of 34 healthy retirees were recruited from Xinxiang Medical University from December 2018 to April 2019. Concentrations of PM constituents including 24 metals and nonmetallic elements and 6 ions, and 5 biomarkers of neural damage including brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL), neuron-specific enolase (NSE), protein gene product 9.5 (PGP9.5), and S100 calcium-binding protein B (S100B) in serum were measured. A linear mixed-effect model was employed to estimate the association of PM and its constituents with neural damage biomarkers. Modification effects of glutathione S-transferase theta 1 gene () polymorphism, sex, education, and physical activity on PM exposure with neural damage were explored. PM and its key constituents were significantly associated with neural damage biomarkers. A 10 μg/m increase in PM concentration was associated with 2.09% (95% CI, 39.3-76.5%), 100% (95% CI, 1.73-198%), and 122% (95% CI, 20.7-222%) increments in BDNF, NfL, and PGP9.5, respectively. Several constituents such as Cu, Zn, Ni, Mn, Sn, V, Rb, Pb, Al, Be, Cs, Co, Th, U, Cl, and F were significantly associated with NfL. The estimated association of PM with NSE in -sufficient volunteers was significantly higher than that in -null volunteers. Therefore, short-term PM exposure was associated with neural damage, and expression levels modified the PM-induced adverse neural effects.
细颗粒物（PM）暴露与各种不良健康影响有关，如呼吸道和心血管疾病。本研究旨在评估 PM 与神经损伤生物标志物的关联。2018 年 12 月至 2019 年 4 月，从新乡医学院共招募了 34 名健康退休人员。测量了血清中 PM 成分（包括 24 种金属和非金属元素以及 6 种离子）和 5 种神经损伤生物标志物（脑源性神经营养因子（BDNF）、神经丝轻链（NfL）、神经元特异性烯醇化酶（NSE）、蛋白基因产物 9.5（PGP9.5）和 S100 钙结合蛋白 B（S100B））的浓度。采用线性混合效应模型估计 PM 及其成分与神经损伤生物标志物的关联。探讨谷胱甘肽 S-转移酶 theta 1 基因（）多态性、性别、教育和体力活动对 PM 暴露与神经损伤的修饰作用。PM 及其关键成分与神经损伤生物标志物显著相关。PM 浓度增加 10μg/m 与 BDNF、NfL 和 PGP9.5 分别增加 2.09%（95%CI，39.3-76.5%）、100%（95%CI，1.73-198%）和 122%（95%CI，20.7-222%）。Cu、Zn、Ni、Mn、Sn、V、Rb、Pb、Al、Be、Cs、Co、Th、U、Cl 和 F 等几种成分与 NfL 显著相关。PM 与 NSE 的估计关联在-不足志愿者中显著高于-null 志愿者。因此，短期 PM 暴露与神经损伤有关，表达水平修饰了 PM 引起的不良神经效应。
