重复外周磁刺激结合运动想象过程中皮质脊髓兴奋性的时程变化。
Time course changes in corticospinal excitability during repetitive peripheral magnetic stimulation combined with motor imagery.
机构信息
Department of Occupational Therapy, Niigata University of Health and Welfare, Niigata, Japan.
Department of Occupational Therapy, Niigata University of Health and Welfare, Niigata, Japan.
出版信息
Neurosci Lett. 2022 Feb 6;771:136427. doi: 10.1016/j.neulet.2021.136427. Epub 2021 Dec 28.
Repetitive peripheral magnetic stimulation (rPMS) induces proprioceptive afferents and facilitates corticospinal excitability. Short-term sessions of rPMS combined with motor imagery (MI) enhance corticospinal excitability more than rPMS alone. However, it is not clear how long the intervention of rPMS combined with MI would be needed to facilitate corticospinal excitability. Therefore, we investigated the time course change in corticospinal excitability during the combination of rPMS and MI. Thirteen healthy volunteers participated in a 20-min intervention under the following three experimental conditions on different days: rPMS, MI, and rPMS combined with MI (rPMS + MI). In the rPMS and rPMS + MI, the participants were delivered rPMS, which was 25 Hz, 2 s/train at 1.5 × of the train intensity induced muscle contractions, through the wrist extensor muscles. In the MI and rPMS + MI, the participants repeatedly imagined wrist movements for 2 s. Motor evoked potentials (MEPs) were recorded from the extensor carpi radialis (ECR) and flexor carpi radialis (FCR) muscles every 5 min for each condition. The MEP amplitudes of the ECR after > 10 min of intermittent rPMS combined with MI were greater than baseline. The MEP amplitude of the ECR in rPMS + MI was greater than that in rPMS condition after 20 min of intervention. The present results suggest that over 10 min of intermittent rPMS combined with MI facilitates corticospinal excitability, and that the effect of rPMS combined with MI on corticospinal excitability might be greater than that of rPMS alone.
重复性外周磁刺激（rPMS）可诱导本体感觉传入，并促进皮质脊髓兴奋性。rPMS 与运动想象（MI）的短期联合治疗比单独 rPMS 更能增强皮质脊髓兴奋性。然而，尚不清楚 rPMS 与 MI 的联合干预需要多长时间才能促进皮质脊髓兴奋性。因此，我们研究了 rPMS 与 MI 联合作用期间皮质脊髓兴奋性的时程变化。13 名健康志愿者在不同天分别接受以下三种实验条件下的 20 分钟干预：rPMS、MI 和 rPMS 与 MI 联合（rPMS+MI）。在 rPMS 和 rPMS+MI 中，通过腕伸肌给予 25Hz、2s/ 次、1.5 倍次刺激强度诱发肌肉收缩的 rPMS。在 MI 和 rPMS+MI 中，参与者反复想象腕部运动 2s。在每种条件下，每隔 5min 记录来自桡侧腕伸肌（ECR）和桡侧腕屈肌（FCR）的运动诱发电位（MEP）。在间歇 rPMS 与 MI 联合作用>10min 后，ECR 的 MEP 振幅大于基线。在 20min 的干预后，rPMS+MI 中的 ECR 的 MEP 振幅大于 rPMS 条件。本研究结果表明，超过 10min 的间歇性 rPMS 与 MI 联合作用可促进皮质脊髓兴奋性，并且 rPMS 与 MI 的联合作用对皮质脊髓兴奋性的影响可能大于单独 rPMS。
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