Perino L E, Gholson C F, Goff J S
J Clin Gastroenterol. 1987 Jun;9(3):286-9. doi: 10.1097/00004836-198706000-00009.
Our experience and review of the literature suggests that perforation follows fiberoptic sclerotherapy at an incidence of 1-6% per patient. Perforation is delayed for 2-14 days after the procedure and is due to chemical necrosis of the esophageal wall. The risk of perforation is higher in Child's class C patients. The use of large volumes or high concentrations of sclerosant may increase the risk of perforation. To reduce this risk, we suggest a cautious approach to Child's class C patients, with no more than two sclerosis sessions during the first 2 weeks of treatment using less than or equal to 10 ml of 1.5% sodium tetradecyl sulfate per session.
我们的经验及文献回顾表明，光纤硬化疗法后穿孔的发生率为每位患者1%-6%。穿孔在术后2-14天出现，是由食管壁化学性坏死所致。Child C级患者穿孔风险更高。使用大剂量或高浓度硬化剂可能会增加穿孔风险。为降低此风险，我们建议对Child C级患者采取谨慎方法，在治疗的前2周内进行不超过两次硬化治疗，每次使用不超过10 ml的1.5%十四烷基硫酸钠。
