Nakajima Medical Clinic, Kobe, Japan.
Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine, Kobe, Japan;
In Vivo. 2022 Jan-Feb;36(1):446-449. doi: 10.21873/invivo.12723.
BACKGROUND/AIM: Measuring the fraction of exhaled nitric oxide (FeNO) is useful in the diagnosis of asthma and cough variant asthma. The aim of this study was to clarify the significance of measuring the FeNO in the differential diagnosis of acute cough.
We analyzed 80 patients who visited the clinic with the chief complaint of acute cough having experienced an asthma-like episode from January 2014 to July 2015.
Infectious cough alone was present in 21% of patients, while 30% had asthmatic cough alone and 49% had a combination of infectious and asthmatic cough. The values of FeNO in those with asthmatic cough (30.4±24.7 ppb) and asthmatic/infectious cough (33.2±17.4 ppb) were significantly higher than those with just infectious cough (13.7±3.2 ppb) (p=0.0089 and p<0.0001, respectively).
FeNO measurement is useful for distinguishing asthmatic diseases, even in the differential diagnosis of acute cough.
背景/目的：测量呼出气一氧化氮（FeNO）的分数在哮喘和咳嗽变异性哮喘的诊断中很有用。本研究的目的是阐明测量 FeNO 在急性咳嗽鉴别诊断中的意义。
我们分析了 2014 年 1 月至 2015 年 7 月因哮喘样发作而就诊的 80 例以急性咳嗽为主要症状的患者。
单纯感染性咳嗽占 21%，单纯哮喘性咳嗽占 30%，感染性和哮喘性咳嗽并存占 49%。哮喘性咳嗽（30.4±24.7 ppb）和哮喘/感染性咳嗽（33.2±17.4 ppb）患者的 FeNO 值明显高于单纯感染性咳嗽患者（13.7±3.2 ppb）（p=0.0089 和 p<0.0001）。
FeNO 测量有助于鉴别哮喘性疾病，即使在急性咳嗽的鉴别诊断中也是如此。
