Department of Neurology, Seoul National University Hospital, Seoul, South Korea.
Department of Neurology, College of Medicine, Seoul National University, Seoul, South Korea.
J Alzheimers Dis. 2022;85(4):1835-1844. doi: 10.3233/JAD-215399.
Cerebral white matter lesions (WML) are related to a higher risk of vascular and Alzheimer's dementia. Moreover, oligomerized amyloid-β (OAβ) can be measured from blood for dementia screening.
We aimed to investigate the relationship of plasma OAβ levels with clinical and radiological variables in a health screening population.
WML, other volumetric parameters of magnetic resonance images, cognitive assessment, and plasma OAβ level were evaluated.
Ninety-two participants were analyzed. The majority of participants' clinical dementia rating was 0 or 0.5 (96.7%). White matter hyperintensities (WMH) increased with age, but OAβ levels did not (r2 = 0.19, p < 0.001, r2 = 0.03, p = 0.10, respectively). No volumetric data, including cortical thickness/hippocampal volume, showed any significant correlation with OAβ. Log-WMH volume was positively correlated with OAβ (r = 0.24, p = 0.02), and this association was significant in the periventricular area. White matter signal abnormalities from 3D-T1 images were also correlated with the OAβ in the periventricular area (p = 0.039). Multivariate linear regression showed that log-WMH values were independently associated with OAβ (B = 0.879 (95% confidence interval 0.098 -1.660, p = 0.028)). Higher tertiles of WMH showed higher OAβ levels than lower tertiles showed (p = 0.044). Using a cutoff of 0.78 ng/mL, the high OAβ group had a larger WMH volume, especially in the periventricular area, than the low OAβ group (p = 0.036).
Both WML and plasma OAβ levels can be early markers for neurodegeneration in the healthcare population. The lesions, especially in the periventricular area, might be related to amyloid pathogenesis, which strengthens the importance of WML in the predementia stage.
脑白质病变（WML）与血管性和阿尔茨海默病痴呆的风险增加有关。此外，可从血液中测量寡聚化的淀粉样β（OAβ），以用于痴呆筛查。
我们旨在研究健康筛查人群中血浆 OAβ 水平与临床和影像学变量的关系。
评估了 WML、磁共振图像的其他容积参数、认知评估和血浆 OAβ 水平。
分析了 92 名参与者。大多数参与者的临床痴呆评定量表（CDR）为 0 或 0.5（96.7%）。脑白质高信号（WMH）随年龄增加而增加，但 OAβ 水平没有增加（r2=0.19，p<0.001，r2=0.03，p=0.10）。包括皮质厚度/海马体积在内的任何容积数据均与 OAβ 无显著相关性。WMH 体积的对数值与 OAβ 呈正相关（r=0.24，p=0.02），且这种相关性在脑室周围区域显著。3D-T1 图像的脑白质信号异常与脑室周围区域的 OAβ 也相关（p=0.039）。多元线性回归显示，WMH 值的对数值与 OAβ 独立相关（B=0.879（95%置信区间 0.098-1.660，p=0.028））。WMH 三分位较高者的 OAβ 水平高于三分位较低者（p=0.044）。使用 0.78ng/ml 的截断值，OAβ 水平较高组的 WMH 体积较大，尤其是在脑室周围区域，高于 OAβ 水平较低组（p=0.036）。
WMH 和血浆 OAβ 水平均可作为医疗保健人群神经退行性变的早期标志物。病变，尤其是脑室周围区域的病变，可能与淀粉样蛋白发病机制有关，这增强了 WML 在痴呆前阶段的重要性。
