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热灌注化疗后阴囊坏死:病例报告及文献复习

Scrotal Necrosis Following Heated Intra-peritoneal Chemotherapy: Case Report and Review of the Literature.

作者信息

Fagih Samiha N, Baghdadi Rana M, Banjer Aeshah Y, Ismail Amal A, Addas Majda A, Shabkah Alaa A, Trabulsi Nora H

机构信息

Department of Surgery, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.

Department of Surgery, International Medical Center, Jeddah, SAU.

出版信息

Cureus. 2021 Dec 23;13(12):e20638. doi: 10.7759/cureus.20638. eCollection 2021 Dec.

DOI:10.7759/cureus.20638
PMID:34976544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8712224/
Abstract

Scrotal necrosis is a rare occurrence that is scarcely reported among patients having undergone heated intra-peritoneal chemotherapy (HIPEC) procedures. Due to anatomic factors and the thermally enhanced cytotoxicity of chemotherapeutic agents, this complication can have debilitating post-operative effects. We herein highlight the presentation of scrotal necrosis in a patient who underwent HIPEC procedure for peritoneal metastasis secondary to colorectal carcinoma, and how it contrasts to previously documented cases of a similar nature. Furthermore, we describe a successful management strategy that consisted of conservative measures followed by surgical debridement and primary repair, and enabled the patient to experience significant functional and cosmetic improvement.

摘要

阴囊坏死是一种罕见的情况,在接受热腹腔内化疗(HIPEC)手术的患者中鲜有报道。由于解剖因素以及化疗药物热增强的细胞毒性,这种并发症可能会产生严重的术后影响。在此,我们重点介绍一名因结直肠癌继发腹膜转移而接受HIPEC手术的患者出现阴囊坏死的情况,以及它与先前记录的类似性质病例的对比。此外,我们描述了一种成功的治疗策略,该策略包括保守措施,随后进行手术清创和一期修复,使患者在功能和外观上都有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/df788745c72e/cureus-0013-00000020638-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/f4682780dfab/cureus-0013-00000020638-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/fadb6481c9ba/cureus-0013-00000020638-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/08c8d5ab0d58/cureus-0013-00000020638-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/df788745c72e/cureus-0013-00000020638-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/f4682780dfab/cureus-0013-00000020638-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/fadb6481c9ba/cureus-0013-00000020638-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/08c8d5ab0d58/cureus-0013-00000020638-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f40/8712224/df788745c72e/cureus-0013-00000020638-i04.jpg

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Scrotal Necrosis Following Heated Intra-peritoneal Chemotherapy: Case Report and Review of the Literature.热灌注化疗后阴囊坏死:病例报告及文献复习
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本文引用的文献

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Delayed genital necrosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with Mitomycin-C.细胞减灭术和含丝裂霉素 C 的腹腔热灌注化疗后生殖器延迟性坏死。
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Peritoneal Involvement Is More Common Than Nodal Involvement in Patients With High-Grade Appendix Tumors Who Are Undergoing Prophylactic Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.在接受预防性细胞减灭术和腹腔内热灌注化疗的高级别阑尾肿瘤患者中,腹膜受累比淋巴结受累更常见。
Dis Colon Rectum. 2017 Nov;60(11):1155-1161. doi: 10.1097/DCR.0000000000000869.
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Platinum agents and mitomycin C-specific complications in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).铂类药物和丝裂霉素 C 相关的细胞减灭术(CRS)和腹腔热灌注化疗(HIPEC)特定并发症。
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The processus vaginalis transection method is superior to the simple prophylactic procedure for prevention of inguinal hernia after radical prostatectomy.在前列腺癌根治术后预防腹股沟疝方面,鞘突横断法优于单纯预防性手术。
Int J Clin Oncol. 2016 Apr;21(2):384-388. doi: 10.1007/s10147-015-0881-9. Epub 2015 Aug 6.
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Scrotal pain and ulceration post HIPEC: a case report.腹腔热灌注化疗术后阴囊疼痛及溃疡:一例报告
J Gastrointest Cancer. 2015 Mar;46(1):60-3. doi: 10.1007/s12029-014-9665-0.
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Cytoreductive surgery and HIPEC in recurrent epithelial ovarian cancer: a prospective randomized phase III study.减瘤手术及腹腔热灌注化疗治疗复发性上皮性卵巢癌:一项前瞻性随机III期研究
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Intraperitoneal chemotherapy against peritoneal carcinomatosis: current status and future perspective.针对腹膜癌病的腹腔内化疗:现状与未来展望
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