氯化镧通过PI3K/Akt信号通路增强卵巢癌细胞对顺铂的耐药性。

Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells PI3K/Akt Pathway.

作者信息

Fang Shanyu, Zhang Ping, Chen Xinping, Liu Fujun, Wang Fen

机构信息

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Department of Otorhinolaryngology Head and Neck Surgery, Jiujiang University Clinical Medical College, Jiujiang University Hospital, Jiujiang, China.

出版信息

Front Med (Lausanne). 2021 Dec 15;8:776876. doi: 10.3389/fmed.2021.776876. eCollection 2021.

Our previous study manifested that lanthanum chloride (LaCl) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl. Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.