Department of Clinical Sciences Malmö, Center for Primary Health Care Research, Institutionen För Kliniska Vetenskaper, Malmö (IKVM), Lund University, Inga-Marie Nilssons gata 53, Wallenberg Laboratory, plan 5, Box 50332, 202 13, Malmö, Sweden.
Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
BMC Gastroenterol. 2022 Jan 3;22(1):3. doi: 10.1186/s12876-021-02075-y.
Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.
The study included a total of 130 women (51-61 years) from the Women's Health in Lund Area (WHILA) study, which included 18 prevalent IBD (diagnosed before baseline) and 47 incident IBD diagnosed during the 17 years (median) follow-up and age- and sampling time-matched controls. Serum ZRP was tested in all participants by ELISA.
The serum ZRP levels were significantly higher in prevalent IBD compared to their matched controls (63.2 ng/ml vs 57.0 ng/ml, p = 0.02), however, no evidence of a difference in ZRP levels was found between the women who developed IBD during the follow-up period and their matched controls (61.2 ng/ml vs 59.7 ng/ml, p = 0.34). Using linear mixed models, we found that the association between serum ZRP levels and prevalent IBD (β = 6.2, p = 0.01), remained after adjusting for potential confounders. Conditional logistic regression models showed no evidence of an association between ZRP level and incident IBD (OR 1.03, p = 0.34).
Higher serum ZRP levels were associated with prevalent IBD, but not with incident IBD in our study samples.
目前关于血清肠紧密连接相关蛋白（ZRP）水平与现患炎症性肠病（IBD）之间关联的证据相互矛盾。此外，与随后发生 IBD 的风险之间的关联仍未得到探索。本研究旨在调查血清 ZRP 水平与现患和新发 IBD 的关联。
该研究共纳入了来自 Lund 地区女性健康研究（WHILA）的 130 名女性（51-61 岁），其中 18 名为现患 IBD（在基线前诊断），47 名为在 17 年（中位数）随访期间诊断为新发 IBD 的患者，以及年龄和采样时间匹配的对照者。所有参与者均通过 ELISA 检测血清 ZRP。
与匹配的对照组相比，现患 IBD 患者的血清 ZRP 水平显著升高（63.2ng/ml 比 57.0ng/ml，p=0.02），但在随访期间发生 IBD 的女性与匹配的对照组之间的 ZRP 水平无差异（61.2ng/ml 比 59.7ng/ml，p=0.34）。使用线性混合模型，我们发现血清 ZRP 水平与现患 IBD 之间的关联（β=6.2，p=0.01），在调整了潜在混杂因素后仍然存在。条件逻辑回归模型显示 ZRP 水平与新发 IBD 之间无关联（OR 1.03，p=0.34）。
在本研究样本中，较高的血清 ZRP 水平与现患 IBD 相关，但与新发 IBD 无关。
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