Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, 7000, Australia.
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
BMC Nephrol. 2022 Jan 3;23(1):2. doi: 10.1186/s12882-021-02627-0.
The relationships of healthy lifestyle scores (HLS) of various kinds in adulthood with the risk of chronic kidney disease (CKD) have been reported, but little is known about the association of childhood lifestyle with later life CKD. This study examined the relationship of HLS from childhood to adulthood with subclinical kidney damage (SKD) in midlife, a surrogate measure for CKD.
Data were collected in an Australian population-based cohort study with 33 years follow-up. 750 participants with lifestyle information collected in childhood (ages 10-15 years) and midlife (ages 40-50 years), and measures of kidney function in midlife were included. The HLS was generated from the sum scores of five lifestyle factors (body mass index, smoking, alcohol consumption, physical activity, and diet). Each factor was scored as poor (0 point), intermediate (1 point), or ideal (2 points). Log-binomial regression was used to investigate the relationship of HLS in childhood and from childhood to adulthood with SKD defined as either 1) estimated glomerular filtration rate (eGFR) 30-60 mL/min/1.73m or 2) eGFR> 60 mL/min/1.73m with urine albumin-creatinine ratio ≥ 2.5 mg/mmol (males) or 3.5 mg/mmol (females), adjusting for socio-demographic factors and the duration of follow-up.
The average HLS was 6.6 in childhood and 6.5 in midlife, and the prevalence of SKD was 4.9% (n = 36). Neither HLS in childhood nor HLS from childhood to adulthood were significantly associated with the risk of SKD in midlife.
A HLS from childhood to adulthood did not predict SKD in this middle-aged, population-based Australian cohort.
成年后各种健康生活方式评分（HLS）与慢性肾脏病（CKD）风险的关系已被报道，但儿童时期生活方式与晚年 CKD 的关系知之甚少。本研究探讨了从儿童期到成年期的 HLS 与中年亚临床肾脏损伤（SKD）的关系，SKD 是 CKD 的替代指标。
本研究数据来自一项澳大利亚人群队列研究，随访时间为 33 年。共纳入了 750 名参与者，他们在儿童期（10-15 岁）和中年期（40-50 岁）时收集了生活方式信息，并在中年期测量了肾功能。HLS 由五个生活方式因素（体重指数、吸烟、饮酒、身体活动和饮食）的总和评分得出。每个因素的评分分别为差（0 分）、中等（1 分）或理想（2 分）。使用对数二项式回归分析了儿童期和从儿童期到成年期的 HLS 与 SKD 的关系，SKD 定义为 1）估计肾小球滤过率（eGFR）为 30-60mL/min/1.73m 或 2）eGFR>60mL/min/1.73m 伴尿白蛋白/肌酐比值≥2.5mg/mmol（男性）或 3.5mg/mmol（女性），并调整了社会人口统计学因素和随访时间。
儿童期平均 HLS 为 6.6，中年期平均 HLS 为 6.5，SKD 的患病率为 4.9%（n=36）。儿童期 HLS 和从儿童期到成年期的 HLS 均与中年 SKD 风险无显著相关性。
在这个澳大利亚的中年人群队列中，从儿童期到成年期的 HLS 并不能预测 SKD。
