桥本甲状腺炎背景下甲状腺乳头状癌的淋巴结转移。
Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto's thyroiditis.
机构信息
Department of Ultrasound, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Department of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
出版信息
BMC Endocr Disord. 2022 Jan 5;22(1):12. doi: 10.1186/s12902-021-00923-2.
BACKGROUND
Whether Hashimoto's thyroiditis (HT) affects the lymph node metastasis of papillary thyroid carcinoma (PTC) remains uncertain. The diagnostic criteria for HT differed in previous studies. Our study focused on analysing the influence of HT on PTC lymph node metastasis (LNM) with stringent diagnostic criteria for HT.
METHODS
A total of 444 patients diagnosed with PTC from 2019 to 2020 were enrolled and divided into two groups: HT group and non-HT group. Diagnostic criteria of HT were as follows: thyroid peroxidase antibody (+) and postoperative histopathology of Hashimoto's disease.
RESULTS
There was no significant difference in the LNM rate between HT group and non-HT group. Patients in the HT group had fewer numbers of metastatic LNs and lower metastatic LNs ratio in central region. In the HT group, age < 55 and tumor size ≥10 mm were independent risk factors for central LNM.
CONCLUSION
The autoimmune response of HT seems to reduce the central lymph node metastasis of HT PTCs. Age < 55 and tumor size ≥10 mm were independent risk factors of central lymph node metastasis in HT PTCs.
背景
桥本甲状腺炎 (HT) 是否影响甲状腺乳头状癌 (PTC) 的淋巴结转移仍不确定。既往研究中 HT 的诊断标准不同。我们的研究集中于使用严格的 HT 诊断标准分析 HT 对 PTC 淋巴结转移 (LNM) 的影响。
方法
共纳入 2019 年至 2020 年诊断为 PTC 的 444 例患者，并分为 HT 组和非 HT 组。HT 的诊断标准为：甲状腺过氧化物酶抗体(+)和桥本氏病的术后组织病理学。
结果
HT 组和非 HT 组的 LNM 率无显著差异。HT 组患者转移淋巴结数量较少，中央区域转移淋巴结比例较低。在 HT 组中，年龄<55 岁和肿瘤大小≥10mm 是中央淋巴结转移的独立危险因素。
结论
HT 的自身免疫反应似乎降低了 HT 型 PTC 的中央淋巴结转移。年龄<55 岁和肿瘤大小≥10mm 是 HT 型 PTC 中央淋巴结转移的独立危险因素。
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