[Hazard criteria and the evaluation of the overall toxic and specific effects of chemical compound exposure].

A differentiated establishment of a chronic action threshold for a population and especially of a subthreshold is a basic hygienic parameter necessary for substantiating safe concentrations of chemical substances. Investigations aimed at detecting the penetration of substances into the cells, their intracellular distribution and ascertaining the extent of deranged biochemical processes localized in subcellular formations are of crucial importance in toxicological experiment.