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肉毒杆菌毒素在乳房重建中的诊断和治疗应用。

Diagnostic and Therapeutic Use of Botox for Breast Reconstruction.

作者信息

Ma Irene T, Yesantharao Pooja, Darrach Halley M, Seither Jennifer G, He Hui, Nguyen Dung H

机构信息

Division of Plastic Surgery, Department of Surgery, Stanford University, CA, USA.

出版信息

Arch Clin Med Case Rep. 2021;5(5):759-770. doi: 10.26502/acmcr.96550419. Epub 2021 Oct 29.

Abstract

INTRODUCTION

Breast reconstruction is most commonly performed using implant-based reconstruction. Patients with subpectoral implant placement with or without latissimus dorsi (LD) muscle coverage can experience muscle pain and animation deformity. Due to minimal literature describing the use of botulinum toxin (BTX-A) treatment for these side effects from implant-based reconstruction, we report our outcomes.

METHODS

A retrospective chart review of breast reconstructive patients for a single surgeon was performed. Patients who underwent BTX-A injection for muscular pain, spasm, or animation deformity were identified and outcomes reviewed. They were also stratified based on radiation treatment and type of muscle flap used.

RESULTS

Eleven patients were identified who had a submuscular pectoralis pocket and/or a pedicled latissimus dorsi flap. Nineteen breasts were treated. The average amount of time from the patient's last surgery to BTX-A injection was 11.2 months. 25-100 units were used per injection with an average of 60 units. Non-irradiated patients had signifycantly lower post-injection capsular contracture Baker grades and significantly lower amounts of BTX-A were injected. Patients who had both pectoralis major muscle and LD implant-reconstruction were significantly less likely to have improvement in pain/tightness. Most patients reported improvement or resolution of their pain and/or animation deformities.

CONCLUSION

Implant-based reconstruction using the pectoralis major and/or LD muscles can be plagued with muscular pain, spasm, and animation deformities. The use of BTX-A is a diagnostic and therapeutic modality for these post-breast reconstruction patients with most patients having resolution of symptoms without the need for additional surgery.

摘要

引言

乳房重建最常用的方法是植入式重建。采用胸肌下植入假体且有或没有背阔肌(LD)肌肉覆盖的患者可能会经历肌肉疼痛和动态畸形。由于描述肉毒杆菌毒素(BTX-A)治疗植入式重建产生的这些副作用的文献很少,我们报告了我们的治疗结果。

方法

对一位外科医生的乳房重建患者进行回顾性病历审查。确定接受BTX-A注射治疗肌肉疼痛、痉挛或动态畸形的患者,并审查其治疗结果。他们还根据放射治疗和所使用的肌皮瓣类型进行分层。

结果

确定了11例患者,他们有胸肌下假体腔隙和/或带蒂背阔肌瓣。共治疗了19个乳房。从患者最后一次手术到BTX-A注射的平均时间为11.2个月。每次注射使用25-100单位,平均60单位。未接受放疗的患者注射后包膜挛缩的贝克分级明显较低,且注射的BTX-A量也明显较少。同时进行胸大肌和LD植入重建的患者疼痛/紧绷改善的可能性明显较小。大多数患者报告疼痛和/或动态畸形有所改善或消失。

结论

使用胸大肌和/或LD肌肉进行植入式重建可能会出现肌肉疼痛、痉挛和动态畸形。对于这些乳房重建后的患者,BTX-A的使用是一种诊断和治疗方式,大多数患者症状得到缓解,无需额外手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7b0/8725655/fabab96f8dcd/nihms-1765904-f0001.jpg

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