Heng Hock Gan, Ramos-Vara José A, Fulkerson Christopher M, Fourez Lindsey M, Knapp Deborah W
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA.
Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, USA.
Vet Radiol Ultrasound. 2022 Mar;63(2):234-239. doi: 10.1111/vru.13051. Epub 2022 Jan 5.
An apex nodule was recently identified in the urinary bladder of Scottish Terriers being screened for bladder cancer at our institution. This prospective, single-center, case series study was performed to better characterize the apex nodule and assess the clinical importance of the nodule. Scottish Terriers ≥6 years of age with no evidence of urinary tract disease underwent urinary tract ultrasonography and urinalysis at 6-month intervals. In dogs with evidence of the apex nodule, ultrasound features such as location, margins, number, echogenicity, size, and shape of the lesion were recorded by a veterinary oncologist and veterinary radiologist. The apex nodule was identified in eight (6%) of 134 dogs in the absence of other detectable bladder disease. Features of the nodules included the following: one nodule per dog, triangular to an oval shape, smooth mucosal covering, well-defined margins, isoechoic to the bladder wall, 2-4 mm at the base, and 4-6 mm protruding into the bladder lumen. In five dogs undergoing multiple ultrasonographic examinations, the nodule did not appear to change over time (up to 3.5 years). Cystoscopy performed in three dogs revealed a column of tissue covered by normal mucosa protruding into the bladder lumen. Histological features consistent with a neoplastic growth were absent. Five dogs remained free of any bladder disease. Three dogs developed urothelial carcinoma at sites distant to the nodule at 8-53 months after the nodule was first observed. Findings indicated that incidental apex nodules could mimic neoplasia and other bladder diseases in Scottish Terriers.
最近在我们机构接受膀胱癌筛查的苏格兰梗犬的膀胱中发现了一个尖部结节。进行这项前瞻性、单中心病例系列研究是为了更好地描述尖部结节的特征，并评估该结节的临床重要性。≥6岁且无泌尿系统疾病证据的苏格兰梗犬每隔6个月接受一次泌尿系统超声检查和尿液分析。对于有尖部结节证据的犬只，兽医肿瘤学家和兽医放射科医生记录病变的超声特征，如位置、边缘、数量、回声性、大小和形状。在134只犬中，有8只（6%）在没有其他可检测到的膀胱疾病的情况下发现了尖部结节。结节的特征如下：每只犬一个结节，呈三角形至椭圆形，黏膜覆盖光滑，边缘清晰，与膀胱壁等回声，基部2 - 4毫米，向膀胱腔内突出4 - 6毫米。在5只接受多次超声检查的犬中，结节在长达3.5年的时间里似乎没有变化。对3只犬进行的膀胱镜检查显示，有一列被正常黏膜覆盖的组织突入膀胱腔。没有发现与肿瘤生长一致的组织学特征。5只犬未出现任何膀胱疾病。3只犬在首次观察到结节后的8 - 53个月，在远离结节的部位发生了尿路上皮癌。研究结果表明，在苏格兰梗犬中，偶然发现的尖部结节可能会模仿肿瘤及其他膀胱疾病。
