BP Clinical Lab Sdn Bhd, Temasya@Glenmarie, Lot 2, Jalan Pendaftar U1/54, Section U1, 40150 Shah Alam, Selangor, Malaysia.
Trop Biomed. 2021 Dec 1;38(4):552-560. doi: 10.47665/tb.38.4.098.
Understanding of antibody kinetics against SARS-CoV-2 and its vaccines is rapidly evolving. This study aims to (1) determine post-vaccination seroprevalence; (2) compare antibody levels between vaccine types and various clinical/demographic determinants; and (3) determine post-vaccination antibody concentrations against time. This is a retrospective cross-sectional study involving 148 healthcare employees all over Malaysia. IgG Spike (RBD), IgM Spike and IgG Nucleocapsid concentration medians were compared using Mann-Whitney U or Kruskal-Wallis tests. Chi Square and Spearman correlation coefficient tests were performed to identify variables associated with antibody titers. A scatter plot of IgG Spike (RBD) against time from last vaccine dose was also plotted. At 1-month post-vaccination, all employees successfully seroconverted regardless of vaccine type, health status and COVID- 19 history. Comirnaty, convalescent, female or Malay vaccinees had significantly higher IgG Spike (RBD) titers compared to their respective counterparts. No correlation was found between age and IgG Spike (RBD) levels. Concentration of all three antibodies waned with time post-vaccination, with IgM Spike and IgG Nucleocapsid waning faster than IgG Spike (RBD).
对 SARS-CoV-2 及其疫苗的抗体动力学的理解正在迅速发展。本研究旨在：(1)确定接种疫苗后的血清阳性率；(2)比较不同疫苗类型与各种临床/人口统计学决定因素之间的抗体水平；(3)确定接种疫苗后针对时间的抗体浓度。这是一项在马来西亚各地的 148 名医疗保健工作者中进行的回顾性横断面研究。使用 Mann-Whitney U 或 Kruskal-Wallis 检验比较 IgG 尖峰（RBD）、IgM 尖峰和 IgG 核衣壳浓度中位数。进行卡方检验和斯皮尔曼相关系数检验，以确定与抗体滴度相关的变量。还绘制了 IgG 尖峰（RBD）与上次疫苗接种剂量后时间的散点图。在接种疫苗后 1 个月，所有员工均成功产生血清反应，无论疫苗类型、健康状况和 COVID-19 病史如何。与各自的对照组相比，Comirnaty、恢复期、女性或马来疫苗接种者的 IgG 尖峰（RBD）滴度显著更高。年龄与 IgG 尖峰（RBD）水平之间未发现相关性。接种疫苗后所有三种抗体的浓度随时间推移而下降，其中 IgM 尖峰和 IgG 核衣壳下降速度快于 IgG 尖峰（RBD）。
Zotero 插件