Xue Qiong, Zhu Yu, Wang Ying, Yang Jian-Jun, Zhou Cheng-Mao
Department of Anesthesiology, Pain and Perioperative Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Scientific Research, Zhaoqing Medical College, Zhaoqing, China.
Front Med (Lausanne). 2021 Dec 23;8:705713. doi: 10.3389/fmed.2021.705713. eCollection 2021.
To develop and validate a nomogram model for predicting postoperative pulmonary complications (PPCs) in patients with diffuse peritonitis undergoing emergency gastrointestinal surgery. We used the least absolute shrinkage and selection operator (LASSO) regression model to analyze the independent risk factors for PPCs in patients with diffuse peritonitis who underwent emergency gastrointestinal surgery. Using R, we developed and validated a nomogram model for predicting PPCs in patients with diffuse peritonitis undergoing emergency gastrointestinal surgery. The LASSO regression analysis showed that AGE, American Society of Anesthesiologists physical status classification (ASA), DIAGNOSIS, platelets (on the 3rd day after surgery), cholesterol (on the 3rd day after surgery), ALBUMIN (on the first day after surgery), and preoperative ALBUMIN were independent risk factors for PPCs in patients with diffuse peritonitis undergoing emergency gastrointestinal surgery. The area under the curve (AUC) value of the nomogram model in the training group was 0.8240; its accuracy was 0.7000, and its sensitivity was 0.8658. This demonstrates that the nomogram has a high prediction value. Also in the test group, the AUC value of the model established by the variables AGE, ASA, and platelets (on the 3rd day after surgery), cholesterol (on the 3rd day after surgery), ALBUMIN (on the first day after surgery), and preoperative ALBUMIN was 0.8240; its accuracy was 0.8000; and its specificity was 0.8986. In the validation group, the same results were obtained. The results of the clinical decision curve show that the benefit rate was also high. Based on the risk factors AGE, ASA, DIAGNOSIS, platelets (on the 3rd day after surgery), cholesterol (on the 3rd day after surgery), ALBUMIN (on the first day after surgery), and preoperative ALBUMIN, the nomogram model established in this study for predicting PPCs in patients with diffuse peritonitis undergoing emergency gastrointestinal surgery has high accuracy and discrimination.
建立并验证一种用于预测急诊胃肠手术弥漫性腹膜炎患者术后肺部并发症(PPCs)的列线图模型。我们使用最小绝对收缩和选择算子(LASSO)回归模型分析急诊胃肠手术弥漫性腹膜炎患者发生PPCs的独立危险因素。利用R语言,我们建立并验证了一种用于预测急诊胃肠手术弥漫性腹膜炎患者PPCs的列线图模型。LASSO回归分析表明,年龄、美国麻醉医师协会身体状况分级(ASA)、诊断、血小板(术后第3天)、胆固醇(术后第3天)、白蛋白(术后第1天)以及术前白蛋白是急诊胃肠手术弥漫性腹膜炎患者发生PPCs的独立危险因素。列线图模型在训练组的曲线下面积(AUC)值为0.8240;其准确率为0.7000,敏感性为0.8658。这表明该列线图具有较高的预测价值。同样在测试组中,由年龄、ASA、血小板(术后第3天)、胆固醇(术后第3天)、白蛋白(术后第1天)以及术前白蛋白这些变量建立的模型的AUC值为0.8240;其准确率为0.8000;特异性为0.8986。在验证组中也得到了相同的结果。临床决策曲线的结果表明获益率也很高。基于年龄、ASA、诊断、血小板(术后第3天)、胆固醇(术后第3天)、白蛋白(术后第1天)以及术前白蛋白这些危险因素,本研究建立的用于预测急诊胃肠手术弥漫性腹膜炎患者PPCs的列线图模型具有较高的准确性和区分度。