Igari T, Tsuchizawa M, Shimamura T
Iwate Labor Welfare Hospital, Hanamaki.
Tohoku J Exp Med. 1987 Oct;153(2):79-86. doi: 10.1620/tjem.153.79.
Tryptophan, its metabolites and related enzyme activity in synovial fluid, blood and urine in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were measured. The levels of tryptophan, kynurenine and anthranilic acid in the synovial fluid higher in RA were than in OA, whereas the xanthurenic acid level was equal in RA and OA. Indoleamine 2, 3-dioxygenase activity in the synovial membrane was higher in RA than in OA. 5-Hydroxytryptamine (5-HT) levels in the synovial fluid and the blood and the 5-hydroxyindole acetic acid (5-HIAA) level in the synovial fluid were essentially the same for both diseases. However, the 5-HIAA level in the serum of RA patients was higher than in those with OA, and the 5-HIAA level in the urine of RA patients was lower than in those with OA. In addition, monoamine oxidase-A and B activity in the synovial fluid of RA patients was decreased than in those with OA. These findings suggest that metabolism of tryptophan is altered in patients with RA.
对类风湿关节炎（RA）和骨关节炎（OA）患者的滑液、血液和尿液中的色氨酸、其代谢产物及相关酶活性进行了测定。RA患者滑液中的色氨酸、犬尿氨酸和邻氨基苯甲酸水平高于OA患者，而黄尿酸水平在RA和OA患者中相当。RA患者滑膜中的吲哚胺2,3-双加氧酶活性高于OA患者。两种疾病患者滑液和血液中的5-羟色胺（5-HT）水平以及滑液中的5-羟吲哚乙酸（5-HIAA）水平基本相同。然而，RA患者血清中的5-HIAA水平高于OA患者，RA患者尿液中的5-HIAA水平低于OA患者。此外，RA患者滑液中的单胺氧化酶-A和-B活性低于OA患者。这些发现表明，RA患者色氨酸代谢发生了改变。
