Department of Epidemiology and Biostatistics, University of Arizona, Tucson, USA.
Department of Health Promotion Sciences, University of Arizona, Tucson, USA.
Breast Cancer Res Treat. 2022 Apr;192(2):423-433. doi: 10.1007/s10549-021-06486-z. Epub 2022 Jan 10.
Short and long sleep duration and poor sleep quality are risk factors for weight gain and cancer mortality. The purpose of this study is to investigate the relationship between sleep and weight change among postmenopausal breast cancer survivors.
Women participating in the Women's Health Initiative who were diagnosed with incident breast cancer between year one and year three were included. Self-reported sleep duration was categorized as ≤ 5 h (short), 6 h, 7-8 h (optimal), and ≥ 9 h (long). Self-reported sleep quality was categorized as poor, average, and above average. Post-diagnosis weight change was the difference of weight closest to, but preceding diagnosis, and year 3 weight. We used linear regression to evaluate sleep duration and sleep quality associations with post-diagnosis weight change adjusted for potential confounders.
Among 1156 participants, 63% were weight stable after diagnosis; average weight gain post cancer diagnosis was 3.2 kg. Six percent of women reported sleeping ≤ 5 h, 26% reported 6 h, 64% reported 7-8 h, and 4% reported ≥ 9 h. There were no differences in adjusted estimates of weight change among participants with short duration (0.37 kg; 95% CI - 0.88, 1.63), or long duration (- 0.56 kg; 95% CI - 2.03, 0.90) compared to optimal duration, nor was there a difference among poor quality (- 0.51 kg; 95% CI - 1.42, 0.41) compared to above average quality.
Among postmenopausal breast cancer survivors, sleep duration and quality were not associated with weight change after breast cancer diagnosis. Future studies should consider capturing change in adiposity and to expand beyond self-reported sleep.
短时间和长时间睡眠以及睡眠质量差是体重增加和癌症死亡的风险因素。本研究旨在探讨绝经后乳腺癌幸存者的睡眠与体重变化之间的关系。
本研究纳入了参加妇女健康倡议（Women's Health Initiative）且在第 1 年至第 3 年内被诊断患有乳腺癌的女性。自我报告的睡眠时间分为≤5 小时（短）、6 小时、7-8 小时（最佳）和≥9 小时（长）。自我报告的睡眠质量分为差、平均和良好。诊断后体重变化是最接近但早于诊断的体重和第 3 年体重的差异。我们使用线性回归来评估睡眠持续时间和睡眠质量与诊断后体重变化的关系，调整了潜在的混杂因素。
在 1156 名参与者中，63%在诊断后体重稳定；诊断后平均体重增加 3.2 公斤。6%的女性报告睡眠时间≤5 小时，26%报告 6 小时，64%报告 7-8 小时，4%报告≥9 小时。与最佳睡眠时间相比，短时间（0.37 公斤；95%CI -0.88, 1.63）或长时间（-0.56 公斤；95%CI -2.03, 0.90）的参与者体重变化的调整估计值没有差异，与平均睡眠时间相比，睡眠质量差（-0.51 公斤；95%CI -1.42, 0.41）的参与者体重变化也没有差异。
在绝经后乳腺癌幸存者中，睡眠持续时间和质量与乳腺癌诊断后体重变化无关。未来的研究应考虑捕获肥胖的变化，并扩大自我报告睡眠以外的范围。
