Li D, Shi W, Lu X, Liu Z, Zhang S, Sun Y, Shi W, Zhu X
Department of Health Toxicology, School of Public Health, Guilin Medical University, Guilin, Guangxi, China.
Bull Exp Biol Med. 2022 Jan;172(3):328-331. doi: 10.1007/s10517-022-05386-6. Epub 2022 Jan 10.
This study was performed to investigate whether okadaic acid (200 ng/kg) produces a protective effect in experimental liver injury induced by intragastric administration of 1000, 2000, and 4000 mg/kg amoxicillin in Sprague-Dawley rats (n=50). The control group was given carboxymethylcellulose sodium solution. Liver injury was assessed by the relative organ weight index, serum ALT activity, and liver malondialdehyde content. Histopathological examination of the liver from rats treated with amoxicillin revealed cell swelling, congestion, apoptosis, and necrosis. The relative liver weight index, ALT activity, and liver malondialdehyde content in these animals were higher than in the control. Administration of okadaic acid reduced the degree of amoxicillin-induced damage to hepatocytes. Thus, okadaic acid can alleviate liver injury caused by amoxicillin.
本研究旨在调查冈田酸（200 ng/kg）对给予1000、2000和4000 mg/kg阿莫西林的Sprague-Dawley大鼠（n = 50）经胃内给药诱导的实验性肝损伤是否具有保护作用。对照组给予羧甲基纤维素钠溶液。通过相对器官重量指数、血清ALT活性和肝脏丙二醛含量评估肝损伤。用阿莫西林治疗的大鼠肝脏的组织病理学检查显示细胞肿胀、充血、凋亡和坏死。这些动物的相对肝脏重量指数、ALT活性和肝脏丙二醛含量高于对照组。给予冈田酸降低了阿莫西林诱导的肝细胞损伤程度。因此，冈田酸可减轻阿莫西林引起的肝损伤。
