Martínez-Ortega Antonio, Flores-Martinez Álvaro, Venegas-Moreno Eva, Dios Elena, Del Can Diego, Rivas Eloy, Kaen Ariel, Cárdenas Ruiz-Valdepeñas Eugenio, Fajardo Elena, Roldán Florinda, González-Rivera Natividad, Oliva Rosario, Fernández-Peña José Ignacio, Soto-Moreno Alfonso, Cano David A
Unidad de Gestión de Endocrinología y Nutrición, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.
Unidad de Gestión de Anatomía Patológica, Unidad de Neuropatología, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
J Clin Med. 2022 Jan 5;11(1):281. doi: 10.3390/jcm11010281.
Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP ( = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence.
颅咽管瘤（CPs）是起源于胚胎的鞍区和鞍上区的罕见肿瘤。CPs的主要治疗方法是手术，但往往不成功。尽管CPs被认为是良性肿瘤，但其复发率相对较高，这可能会影响生活质量。先前的研究报道CPs表达性激素受体，包括雌激素和孕激素受体。在此，我们通过免疫组织化学系统分析了一组特征明确的CP患者（n = 41）中雌激素受体α（ERα）和孕激素受体（PR）的表达，并分析了它们与肿瘤侵袭性特征的潜在关联。相当一部分CPs显示出PR的显著表达。然而，大多数CPs表达低水平的ERα。在CPs中未观察到PR和ERα表达与临床侵袭性特征之间的主要关联。此外，在我们的系列研究中，β-连环蛋白积累与肿瘤复发无关。
