[Analysis for the short-term efficacy and long-term prognosis of laparoscopic and laparotomy radical resection for gallbladder cancer].

To compare the short-term efficacy and long-term prognosis of laparoscopic and laparotomy radical resection for gallbladder cancer(GBC). From January 2010 to December 2020,the clinical data and survival information for 133 patients who underwent radical resection of GBC at the Department of Hepatopancreatobiliary Surgery,Zhejiang Provincial People's Hospital,were retrospectively collected. Eighty patients(23 males and 57 females) underwent laparoscopic radical resection and had a median age((IQR)) of 66.0(12.8)years(range:28.0 to 82.0 years). Fifty-three patients(45 males and 8 females) who received laparotomy were 63.0(6.0)years old(range:45.0 to 80.0 years old). There were no significant differences in age,gender,body mass index,preoperative albumin,preoperative total bilirubin,N stages,vascular invasion,peri-neural invasion or tumor differentiation between the laparoscopic and laparotomy group(all >0.05). But there were significant differences in preoperative CA19-9(=-2.955, =0.003), preoperative ALT level(=-2.801,=0.031) and T stage (χ=19.110,=0.007) between the two groups. A non-parametric test was used for quantitative data. χ test or Fisher exact probability method was used for count data. Patients in the laparoscopic group did not differ from those in the laparotomy group in terms of length of operation,number of lymph node yield,number of positive lymph nodes,the incidence of intraoperative gallbladder rupture,incidence of postoperative bile leakage,abdominal bleeding or abdominal infection,30-day mortality,90-day mortality, the incidence of incision implantation or peritoneal cavity metastasis(all >0.05). Patients in the laparoscopic group showed less intraoperative bleeding(100.0(200.0)ml 400.0(250.0)ml)(=-5.260,<0.01),fewer days with drainage tube indwelling(6.0(3.8)days 7.0(4.0)days)(=-3.351, =0.001), and fewer postoperative days in hospital(8.0(5.0)days 14.0(7.5)days)(=-6.079,<0.01) than those in the laparotomy group. Patients in the laparoscopic group displayed better overall survival (<0.01) and progression-free survival (<0.01). Subgroup analysis for GBC of T1b-T2 and T3 stages revealed comparable overall survival and progression-free survival between the laparoscopic and laparotomy groups (>0.05). Laparoscopic radical resection can achieve long-term survival for GBC comparable to that with open surgery. Laparoscopic radical resection has advantages over open surgery regarding surgical trauma and postoperative recovery.