College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China.
Biol Trace Elem Res. 2022 Oct;200(10):4316-4324. doi: 10.1007/s12011-021-03042-0. Epub 2022 Jan 11.
The trace element selenium (Se) plays an indispensable role in the growth of humans and animals due to its antioxidant function. Mastitis is one of the most important diseases affecting the dairy industry in the world. In recent years, long non-coding RNAs (lncRNAs) have been implicated in a series of cellular processes and disease development processes. RNA-sequencing technology was used to characterize lncRNA profiles and compared transcriptomic dynamics among the control group, the LPS group, and the Se-treated group to highlight the potential roles and functions of lncRNAs in the mammary epithelial cells of dairy cows. We identified 14 specific lncRNAs related to Se and their predicted target genes. KEGG and GO functional annotation was used to elucidate their biological function and the pathways in which they may be involved. The present study provides novel insights for exploring the molecular markers for the protection of Se against mastitis in dairy cows.
微量元素硒（Se）由于其抗氧化功能，在人类和动物的生长中起着不可或缺的作用。乳腺炎是世界范围内影响奶牛养殖业最重要的疾病之一。近年来，长链非编码 RNA（lncRNA）已被涉及一系列细胞过程和疾病发展过程。我们使用 RNA-seq 技术来描述 lncRNA 图谱，并比较对照组、LPS 组和 Se 处理组之间的转录组动态，以突出 lncRNA 在奶牛乳腺上皮细胞中的潜在作用和功能。我们鉴定了 14 个与 Se 相关的特异性 lncRNA 及其预测的靶基因。KEGG 和 GO 功能注释用于阐明它们的生物学功能以及它们可能参与的途径。本研究为探索 Se 对奶牛乳腺炎保护的分子标记提供了新的见解。
