Kansal Anju, Jaswal Gaurav, Garg Shreya, Kang Manraj Singh, Yadav Hanuman Prasad, Banipal Raja Paramjeet Singh, Garg Pardeep, Kaur Taranjeet
MD (Radiotherapy), SMO, Community Health Centre, Sangat, Bathinda, India.
Consultant, Department of Oncology, Onco Life Care Cancer Centre, Chiplun, Ratnagiri, Maharashtra, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1354-S1359. doi: 10.4103/jpbs.jpbs_163_21. Epub 2021 Nov 10.
Breast cancer is the most common cancer in urban and second common in rural Indian women. In India, in spite of the best treatment available being given to the patients they lose their lives because of paucity of diagnostic aids and lack of an organized breast cancer screening program. Early detection, accurate staging, and initiation of appropriate therapy are the key factors for improving the treatment outcome and prognosis of the disease for the patients. Traditional staging methods include clinical examination, blood tests, chest X-ray, ultrasound of the abdomen, and/or skeletal survey. As these tests lack sensitivity and specificity, these are being scaled down. The hybrid positron emission tomography-computerized tomography (PET-CT) is a unique tool in the field of imaging modalities that combines the effectiveness of PET and CT. This study was undertaken to assess the efficacy and accuracy of PET-CT as a single-session staging modality in the very initial stage itself and if it can replace the conventional means of staging.
This was a cross-sectional study conducted in the Radiotherapy department at GGS Medical College and Hospital Faridkot from March 2014 to October 2015. 52 patients with newly diagnosed and histopathologically proven carcinoma breast were staged by conventional modalities (clinical examination, blood tests, X-ray chest, mammography, ultrasonography abdomen, skeletal survey) and by 18F-fluorodeoxyglucose (18F FDG) PET/CT. PET-CT images were used for the detection, localization, staging of tumors and detection, evaluation, and diagnosis of metastatic lesions, disease burden and organ function along with treatment planning and planning therapeutic procedures. Following the completion of initial study, the results of 18F FDG PET-CT staging in comparison with conventional staging method were assessed. Along with this, the accuracy, changes in staging of cases of carcinoma breast and cost-effectiveness of 18F-FDG PET-CT were also studied.
All the pathologic entities identified by conventional imaging were also perceived with 18F-FDG PET/CT. Therefore, we recommend the use of PET/CT as an important imaging modality for initial diagnosis of carcinoma breast.
乳腺癌是印度城市地区最常见的癌症，在农村地区女性中位列第二常见。在印度，尽管为患者提供了现有的最佳治疗，但由于诊断辅助手段匮乏以及缺乏有组织的乳腺癌筛查项目，患者仍会失去生命。早期检测、准确分期以及启动适当治疗是改善患者疾病治疗结果和预后的关键因素。传统的分期方法包括临床检查、血液检测、胸部X光、腹部超声和/或骨骼检查。由于这些检测缺乏敏感性和特异性，它们的使用正在减少。正电子发射断层扫描-计算机断层扫描（PET-CT）是成像模态领域的一种独特工具，它结合了PET和CT的有效性。本研究旨在评估PET-CT作为初始阶段单疗程分期模态的疗效和准确性，以及它是否能够取代传统的分期方法。
这是一项于2014年3月至2015年10月在法里德科特GGS医学院和医院放疗科进行的横断面研究。52例新诊断且经组织病理学证实的乳腺癌患者通过传统方式（临床检查、血液检测、胸部X光、乳房X线摄影、腹部超声、骨骼检查）以及18F-氟脱氧葡萄糖（18F FDG）PET/CT进行分期。PET-CT图像用于肿瘤的检测、定位、分期以及转移病灶的检测、评估和诊断，疾病负担和器官功能评估以及治疗计划和治疗程序规划。在初始研究完成后，评估18F FDG PET-CT分期与传统分期方法相比的结果。与此同时，还研究了18F-FDG PET-CT的准确性、乳腺癌病例分期的变化以及成本效益。
传统成像所识别的所有病理实体也都能通过18F-FDG PET/CT检测到。因此，我们建议将PET/CT用作乳腺癌初始诊断的重要成像模态。
