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直接口服抗凝剂(DOACs):我们是否准备好采用药物遗传学方法?

Direct Oral Anticoagulants (DOAC): Are We Ready for a Pharmacogenetic Approach?

作者信息

Palmirotta Raffaele

机构信息

Interdisciplinary Department of Medicine, School of Medicine, University of Bari Aldo Moro, 70124 Bari, Italy.

出版信息

J Pers Med. 2021 Dec 29;12(1):17. doi: 10.3390/jpm12010017.

Abstract

Anticoagulants play an important role in reducing complications and mortality associated with thromboembolic disorders, and anticoagulant therapy has been progressively enriched over the last few years with numerous new options [...].

摘要

抗凝剂在降低与血栓栓塞性疾病相关的并发症和死亡率方面发挥着重要作用,并且在过去几年中,抗凝治疗已经通过众多新的选择得到了逐步丰富[……]。

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引用本文的文献

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Distinct pleiotropic effects of direct oral anticoagulants on cultured endothelial cells: a comprehensive review.
Front Pharmacol. 2023 Sep 29;14:1244098. doi: 10.3389/fphar.2023.1244098. eCollection 2023.

本文引用的文献

2
Pharmacogenetics of Bleeding and Thromboembolic Events in Direct Oral Anticoagulant Users.
Clin Pharmacol Ther. 2021 Sep;110(3):768-776. doi: 10.1002/cpt.2316. Epub 2021 Jun 26.
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Pharmacogenetics to guide cardiovascular drug therapy.
Nat Rev Cardiol. 2021 Sep;18(9):649-665. doi: 10.1038/s41569-021-00549-w. Epub 2021 May 5.
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The Impact of ABCB1 and CES1 Polymorphisms on Dabigatran Pharmacokinetics in Healthy Chinese Subjects.
Pharmgenomics Pers Med. 2021 Apr 23;14:477-485. doi: 10.2147/PGPM.S291723. eCollection 2021.
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Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review.
J Pers Med. 2021 Jan 11;11(1):37. doi: 10.3390/jpm11010037.
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Pharmacogenomics. 2019 Nov;20(16):1113-1117. doi: 10.2217/pgs-2019-0149.
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Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science. 2019 Feb 15;363(6428):753-756. doi: 10.1126/science.aav7102.

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