Department of Emergency Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois.
Endocr Pract. 2022 Apr;28(4):372-377. doi: 10.1016/j.eprac.2022.01.006. Epub 2022 Jan 25.
In the United States, hypoglycemic events contribute to 100 000 emergency department (ED) visits, costing $120 million annually. Hypoglycemia hinders glycemic management in people living with diabetes. Glucagon is the first line of treatment for severe hypoglycemia that is administrable by a caregiver in a nonclinical setting. However, there is a paucity of evidence on how frequently glucagon is prescribed for the anticipatory management of hypoglycemia, especially in ED.
A retrospective study of patients seen with hypoglycemic events in an urban ED between 2016 and 2018 was performed to characterize gaps in prescription and use of glucagon for the anticipatory management of severe hypoglycemia.
We identified 232 patients with a documented history of type 1 diabetes mellitus or type 2 diabetes mellitus who were seen in the ED with hypoglycemia. The majority of the patients were women (59%), African American (57%), and covered by public insurance (76%). Eighty-four percent of the patients had type 2 diabetes mellitus, 75% were receiving treatment with hypoglycemic medications, and 61% were receiving treatment with insulin. The prevalence of glucagon prescription was only 3% in this sample, and only 12% of the patients had received formal diabetes education in the year before the ED visit.
Despite its proven efficacy in the management of severe hypoglycemia, glucagon is underused. This may be due to the lack of awareness, education, or training among both providers and patients. ED providers should be educated on prescribing glucagon and its use as a tool for the self-management of hypoglycemia. Patients at risk of hypoglycemia and their families need to be educated on the efficacy and use of glucagon.
在美国,低血糖事件导致 10 万人前往急诊部(ED)就诊,每年耗费 1.2 亿美元。低血糖会妨碍糖尿病患者的血糖管理。在非临床环境中,胰高血糖素是治疗严重低血糖的一线药物,可由护理人员给药。然而,对于胰高血糖素在 ED 中用于低血糖预防性管理的使用频率,相关证据却很少。
对 2016 年至 2018 年在城市 ED 中因低血糖就诊的患者进行了回顾性研究,以明确在低血糖预防性管理中胰高血糖素处方和使用方面存在的差距。
我们共识别出 232 例有 1 型或 2 型糖尿病病史的患者,这些患者在 ED 中因低血糖就诊。大多数患者为女性(59%)、非裔美国人(57%)和有公共保险(76%)。84%的患者患有 2 型糖尿病,75%正在接受低血糖药物治疗,61%正在接受胰岛素治疗。在该样本中,胰高血糖素的处方率仅为 3%,并且只有 12%的患者在 ED 就诊前的一年内接受过正规的糖尿病教育。
尽管胰高血糖素在严重低血糖管理中的疗效已得到证实,但它的使用却不足。这可能是由于提供者和患者都缺乏认识、教育或培训。ED 提供者应接受关于开处方和使用胰高血糖素的教育,将其作为低血糖自我管理的工具。有低血糖风险的患者及其家属需要接受关于胰高血糖素的疗效和使用的教育。