完全突变体和镶嵌突变体起源的分子基础。
The molecular basis of the origin of complete and mosaic mutants.
作者信息
Dianov G L, Vasyunina E A, Ovchinnikova L P, Sinitsina O I, Salganik R I
出版信息
Mutat Res. 1986 Jan-Feb;159(1-2):41-6. doi: 10.1016/0027-5107(86)90110-7.
PMID:3510372
Abstract
To study the molecular basis of the origin of complete and mosaic mutants, pBR322 plasmids with damage to one or both DNA strands were constructed by limited chemical modification of plasmid DNA. Damage to one strand of DNA resulted in the induction of predominantly mosaic mutants. Data were obtained indicating that complete mutations arise as a result of damage to both strands in the region of the mutated gene.
摘要
为了研究完全突变体和嵌合突变体起源的分子基础，通过对质粒DNA进行有限的化学修饰，构建了单链或双链DNA受损的pBR322质粒。单链DNA损伤主要诱导嵌合突变体的产生。获得的数据表明，完全突变是由于突变基因区域的双链损伤所致。
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