Design, molecular docking study of synthesised -heteroaryl substituted gallamide derivatives and their antibacterial assessment.

A series of -heteroaryl substituted Gallamide derivatives were synthesised and the obtained structures were further confirmed by different spectral studies. For antibacterial activity, the synthesised compounds were evaluated against three UTI (Urinary Tract Infection) bacterial strains including and . Furthermore, the designed compounds were docked with bacterial DNA gyrase and dihydropteroate synthase. All the compounds had shown good inhibition against whereas compound has produced significant inhibition at 28 and 26 mm against and respectively. The MIC value of the conjugate and was 3.12 and 6.25 μg/mL against and respectively. Compound 3,4,5-trihydroxy--(4-(-(5-methyl isoxazol-3-yl) sulfamoyl) phenyl)benzamide had shown the highest binding energy against both the targets along with good antibacterial action.