Fernando Michael B, Brennand Kristen J
Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA.
Nash Family Department of Neuroscience, Friedman Brain Institute, Pamela Sklar Division of Psychiatric Genomics, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA.
Cell Stem Cell. 2022 Feb 3;29(2):181-183. doi: 10.1016/j.stem.2022.01.004.
Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using "assembloids" from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.
在皮质神经发育过程中，GABA能中间神经元的异常迁移与蒂莫西综合征有关，但其潜在机制仍不清楚。在本期《细胞·干细胞》杂志中，比雷等人利用患者的“组装体”对发育中的脑回路进行建模，确定了一种机械化学驱动的中间神经元迁移效率低下的双峰机制。
