Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
Schizophr Res. 2022 Mar;241:161-170. doi: 10.1016/j.schres.2022.01.029. Epub 2022 Feb 3.
The Cognitive Assessment Interview (CAI) is an interview-based scale developed to measure cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). Previous studies demonstrated good psychometric properties of the CAI. However, only relatively small samples of SCZ were investigated. This study aimed to determine in a large sample of SCZ (N = 580) the relationships of the Italian Version of the CAI with measures of cognitive performance and functional capacity and real-life functioning, using state-of-the-art instruments.
Intraclass correlation coefficients (ICCs) and Cronbach's alpha were calculated to examine the CAI's inter-rater reliability and internal consistency. Pearson's correlation coefficients were used to evaluate relationships between CAI global and domain composite scores with neurocognition, social cognition, functional capacity, and functioning.
The inter-rater reliability and internal consistency were good to excellent. The CAI global composite score showed a strong correlation with the MATRICS Consensus Cognitive Battery (MCCB) composite score (r = -0.50) and moderate/strong associations with measures of functional capacity (-0.46 < r < -0.52) and real-life functioning (-0.30 < r < -0.51). Finally, CAI composite social cognition score correlated moderately with the Facial Emotion Identification Test (r = -0.31) and two subscales of the Awareness of Social Inference Test (-0.32 < r < -0.34).
The study suggests that CAI is a valid co-primary measure for clinical trials and a suitable instrument to screen impairment in neurocognitive and social cognitive domains and its impact on functioning in SCZ in everyday clinical practice.
认知评估访谈（CAI）是一种基于访谈的量表，旨在测量精神分裂症（SCZ）患者的认知障碍及其对功能的影响。先前的研究表明 CAI 具有良好的心理测量特性。然而，仅对相对较小的 SCZ 样本进行了研究。本研究旨在通过使用最先进的工具，在一个大的 SCZ 样本（N=580）中确定意大利版 CAI 与认知表现、功能能力和现实生活功能的测量之间的关系。
计算组内相关系数（ICCs）和克朗巴赫的α值，以检验 CAI 的评分者间信度和内部一致性。使用皮尔逊相关系数评估 CAI 总分和领域综合评分与神经认知、社会认知、功能能力和功能的关系。
评分者间信度和内部一致性良好至优秀。CAI 总分与 MATRICS 共识认知电池（MCCB）总分呈强相关（r=-0.50），与功能能力（-0.46<r<-0.52）和现实生活功能（-0.30<r<-0.51）的测量呈中度/强关联。最后，CAI 综合社会认知评分与面部情绪识别测试（r=-0.31）和社会推理意识测试的两个分量表中度相关（-0.32<r<-0.34）。
研究表明 CAI 是临床试验的有效共同主要测量指标，也是筛查神经认知和社会认知领域障碍及其对 SCZ 日常临床实践中功能影响的合适工具。
