NHP66 生物活性 Cage 在短道速滑颈椎损伤患者中的疗效。
Efficacy of NHP66 Bioactive Cage on Patients with Cervical Spine Injury in Short-Track Speed Skating.
机构信息
Department of Orthopaedics, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000 Hebei, China.
Department of Orthopaedics, The First Hospital Of QinHuangDao, Qinhuangdao City, 066000 Hebei, China.
出版信息
Comput Math Methods Med. 2022 Jan 29;2022:6088398. doi: 10.1155/2022/6088398. eCollection 2022.
BACKGROUND
Short-track speed skating (STSS) is an extreme sport in pursuit of extreme speed and explosive force. In such a sport, once athletes fall down, they are susceptible to serious cervical spine injury (CSI) under the inertia of high-velocity movement. Nanohydroxyapatite/polyamide 66 (NHP66) bioactive cage is a high-tech product of nanotechnology in the medical field in recent years. With a structure similar to that of human cortical bone, NHP66 bioactive cage has extremely high toughness and strength, which tailors to the needs of STSS.
OBJECTIVE
This study mainly analyzed the therapeutic effect of NHP66 on patients with CSI in STSS, aiming to provide new opportunities for the treatment of this patient population.
METHODS
A total of 51 patients with CSI treated in our hospital were enrolled, including 19 cases of short-track speed skaters (observation group) and 32 cases of car accidents, falls from heights, or collision injuries (control group). The relevant surgical indicators (operation time, intraoperative blood loss, etc.), the incidence of adverse reactions, the Cobb angle of cervical lordosis before and after surgery, and the fusion segment height of the cage were observed and compared between the two groups. Postoperative pain was evaluated by the visual analog scale (VAS), improvement of spinal cord injury was assessed by the American Spinal Cord Injury Association (ASIA) Impairment Scale, and bone fusion, bone subsidence, and other motor functions were assessed by the Japanese Orthopaedic Association (JOA) score rating system.
RESULTS
The operation time, intraoperative blood loss, and incidence of adverse reactions in the observation group were significantly lower than those in the control group. The Cobb angle of cervical lordosis and the fusion segment height of cage increased significantly higher in both groups after surgery. In addition, the VAS scores of the observation group 2 h and 3 d after operation were significantly lower than those of the control group. In terms of improvement of spinal cord injury, ASIA and JOA scores in the observation group were significantly higher than those before treatment and in the control group. There was no significant difference in bone fusion activity between the two groups.
CONCLUSIONS
In this study, it is found through experiments that NHP66 has higher safety and application value than autogenous iliac bone, confirming that NHP66 can achieve significant results as a cage for anterior cervical decompression and iliac bone graft fusion and internal fixation in short-track speed skaters after CSI.
背景
短道速滑(STSS)是一项追求极速和爆发力的极限运动。在这项运动中,运动员一旦摔倒,在高速运动的惯性下,很容易造成严重的颈椎损伤(CSI)。纳米羟基磷灰石/聚酰胺 66(NHP66)生物活性笼是近年来医学领域纳米技术的高科技产品。NHP66 生物活性笼具有与人皮质骨相似的结构,具有极高的韧性和强度,符合 STSS 的需求。
目的
本研究主要分析 NHP66 治疗 STSS 中 CSI 患者的疗效,旨在为该患者群体的治疗提供新的机会。
方法
选取我院收治的 51 例 CSI 患者,其中短道速滑运动员 19 例(观察组),车祸、高处坠落、碰撞伤 32 例(对照组)。观察两组患者的相关手术指标(手术时间、术中出血量等)、不良反应发生率、术后颈椎前凸 Cobb 角、笼融合节段高度,并进行比较。采用视觉模拟评分(VAS)评估术后疼痛,采用美国脊髓损伤协会(ASIA)损伤量表评估脊髓损伤改善情况,采用日本矫形协会(JOA)评分评定系统评估骨融合、骨下沉等运动功能。
结果
观察组的手术时间、术中出血量和不良反应发生率明显低于对照组,术后颈椎前凸 Cobb 角和笼融合节段高度明显高于对照组。此外,观察组术后 2h 和 3d 的 VAS 评分明显低于对照组。在脊髓损伤改善方面,观察组的 ASIA 和 JOA 评分明显高于治疗前和对照组。两组骨融合活性无明显差异。
结论
通过实验发现,NHP66 比自体髂骨具有更高的安全性和应用价值,证实 NHP66 可作为 CSI 后短道速滑运动员前路颈椎减压髂骨植骨融合内固定的笼,取得显著效果。