Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.
Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Australas J Dermatol. 2022 May;63(2):e159-e161. doi: 10.1111/ajd.13801. Epub 2022 Feb 8.
Anticoagulant-induced skin necrosis is a rare and potentially life-threatening complication of anticoagulant therapy. The majority of cases of anticoagulant-induced skin necrosis have been attributed to warfarin, known as warfarin-induced skin necrosis (WISN). The use of anticoagulation reversal agents such as Prothrombinex-VF in the development of WISN is not a commonly documented phenomenon. The authors present a case of WISN post-recommencement of warfarin and the use of Prothrombinex-VF.
抗凝剂诱导的皮肤坏死是抗凝治疗罕见且潜在危及生命的并发症。大多数抗凝剂诱导的皮肤坏死病例归因于华法林，称为华法林诱导的皮肤坏死（WISN）。在 WISN 的发展中使用抗凝逆转剂（如 Prothrombinex-VF）并非常见的现象。作者报告了华法林重新开始使用和 Prothrombinex-VF 治疗后发生 WISN 的病例。
