华法林导致使用抗凝逆转剂后的皮肤坏死。

Warfarin-induced skin necrosis after the use of an anticoagulation reversal agent.

机构信息

Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

出版信息

Australas J Dermatol. 2022 May;63(2):e159-e161. doi: 10.1111/ajd.13801. Epub 2022 Feb 8.

DOI:10.1111/ajd.13801

PMID:35133665

Abstract

Anticoagulant-induced skin necrosis is a rare and potentially life-threatening complication of anticoagulant therapy. The majority of cases of anticoagulant-induced skin necrosis have been attributed to warfarin, known as warfarin-induced skin necrosis (WISN). The use of anticoagulation reversal agents such as Prothrombinex-VF in the development of WISN is not a commonly documented phenomenon. The authors present a case of WISN post-recommencement of warfarin and the use of Prothrombinex-VF.

摘要

抗凝剂诱导的皮肤坏死是抗凝治疗罕见且潜在危及生命的并发症。大多数抗凝剂诱导的皮肤坏死病例归因于华法林，称为华法林诱导的皮肤坏死（WISN）。在 WISN 的发展中使用抗凝逆转剂（如 Prothrombinex-VF）并非常见的现象。作者报告了华法林重新开始使用和 Prothrombinex-VF 治疗后发生 WISN 的病例。