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坦桑尼亚西北部小儿脑积水:布加迪医疗中心的临床特征和早期手术结果的描述性横断面研究。

Pediatric Hydrocephalus in Northwest Tanzania: A Descriptive Cross-Sectional Study of Clinical Characteristics and Early Surgical Outcomes from the Bugando Medical Centre.

机构信息

Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway.

Division of Child Neurology, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

出版信息

World Neurosurg. 2022 May;161:e339-e346. doi: 10.1016/j.wneu.2022.02.003. Epub 2022 Feb 5.

Abstract

OBJECTIVES

In this study, we present data from a neurosurgical training program in Tanzania for the treatment of pediatric hydrocephalus. The objectives of the study were to identify the demographics and clinical characteristics of pediatric patients with hydrocephalus who were admitted to Bugando Medical Centre in Mwanza, Tanzania, as well as to describe their surgical treatment and early clinical outcomes.

METHODS

This cross-sectional study included 38 pediatric patients. Physical examinations were conducted pre- and postoperatively, and their mothers completed a questionnaire providing demographic and clinical characteristics.

RESULTS

There was a slight preponderance of male sex (21/38; 55.3%) with median age at the time of admission of 98.5 days. The majority of patients were surgically treated (33/38; 86.8%). Among those surgically treated, most received a ventriculoperitoneal shunt (23/33; 69.7%), whereas 7 were treated with an endoscopic third ventriculostomy (7/33; 21.2%). At the time of admission, the majority of patients (86%) had head circumferences that met criteria for macrocephaly. The median time between admission and surgery was 23 days (2-49 days). Overall, 5 patients (13.2%) died, including 2 who did not receive surgical intervention.

CONCLUSIONS

We found that in our population, pediatric patients with hydrocephalus often present late for treatment with additional significant delays prior to receiving any surgical intervention. Five patients died, of whom 2 had not undergone surgery. Our study reinforces that targeted investments in clinical services are needed to enable access to care, improve surgical capacity, and alleviate the burden of neurosurgical disease from pediatric hydrocephalus in sub-Saharan Africa.

摘要

目的

本研究介绍了坦桑尼亚神经外科培训项目治疗小儿脑积水的资料。研究目的是确定在坦桑尼亚姆万扎的布根多医学中心收治的小儿脑积水患者的人口统计学和临床特征,描述他们的手术治疗和早期临床结果。

方法

本横断面研究纳入了 38 名儿科患者。在术前和术后进行体格检查,他们的母亲完成了一份问卷,提供人口统计学和临床特征。

结果

男性略占优势(21/38;55.3%),入院时的中位年龄为 98.5 天。大多数患者接受了手术治疗(33/38;86.8%)。在接受手术治疗的患者中,大多数接受了脑室-腹腔分流术(23/33;69.7%),而 7 例接受了内镜第三脑室造瘘术(7/33;21.2%)。入院时,大多数患者(86%)的头围符合大头畸形标准。入院至手术的中位时间为 23 天(2-49 天)。总体而言,5 名患者(13.2%)死亡,其中 2 名未接受手术干预。

结论

我们发现,在我们的人群中,小儿脑积水患者往往就诊较晚,在接受任何手术干预之前还存在额外的显著延迟。5 名患者死亡,其中 2 名未接受手术。我们的研究再次强调,需要对临床服务进行有针对性的投资,以确保获得治疗,提高手术能力,并减轻撒哈拉以南非洲地区小儿脑积水的神经外科疾病负担。

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