2008年至2018年间中国哮喘和/或鼻炎患者的环境及致敏情况变化

Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China.

作者信息

Wang Wanjun, Wang Jianhong, Song Guihua, Xie Hua, Lin Xiaoping, Chai Ruonan, Zhu Rongfei, He Yong, Tang Jun, Wang Junge, Yang Jinghua, Zhi Lili, Wu Lin, Jiang Yan, Zhou Xiaoqin, Huang Dongming, Wang Ning, Xu Rui, Gao Yuan, Chen Zhimin, Liu Jinling, Han Xiaoli, Tan Guolin, Wu Jinzhun, Zhao Deyu, Chen Jianjun, Zhang Xiwei, Li Mengrong, Sun Yuemei, Jiang Yi, Zhang Weitian, Qiu Qianhui, Liu Chuanhe, Yin Jie, Hao Guodong, Li Huabin, Xu Yongsheng, Chen Shaohua, Zhang Hua, Chen Shi, Meng Juan, Zeng Dan, Tang Wei, Hao Chuangli, Li Jing, Zhong Nanshan

机构信息

Department of Allergy and Clinical Immunology National Clinical Research Center for Respiratory Disease State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University Guangzhou China.

The First People's Hospital of Yibin Yibin Sichuan China.

出版信息

Clin Transl Allergy. 2022 Feb 2;12(2):e12116. doi: 10.1002/clt2.12116. eCollection 2022 Feb.

DOI:10.1002/clt2.12116

PMID:35136540

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8809046/

Abstract

BACKGROUND

Little is known about the changes in allergen sensitization in China secondary to the environmental variations over the past decade. We aimed at investigating the variations in sensitization among asthma and/or rhinitis patients in China between 2008 and 2018.

METHODS

This study analyzed cross-sectional data from national surveys conducted in China in 2008 and 2018. After finishing the questionnaire, participants underwent serum specific IgE measurements. A total of 2322 and 2798 patients were enrolled in 2008 and 2018, respectively. The significance of differences in sensitization rates among four regions of China were assessed. Correlation analysis was used to identify the associations of sensitization with climate change and planting of between the two surveys.

RESULTS

Compared with 2008, the general sensitization rate to mites significantly increased in 2018, which ranked highest among all tested allergens. Sensitization to pollens, especially , showed the greatest increase in the north. The annual mean temperature, rainfall and relative humidity in all four regions, and the coverage in the northeastern area, increased significantly in 2018 as compared with 2008. From 2008 to 2018, an increase in sensitization was significantly associated with an increase in relative humidity ( = 0.54, = 0.037). The increase in sensitization was significantly associated with the increase in the planting area ( = 0.67, = 0.006) and with a decrease in rainfall ( = -0.59, = 0.021).

CONCLUSIONS

House dust mites remain the most important allergen in Chinese individuals with asthma and/or rhinitis. Pollen sensitization dramatically increased in northern China. Increases in sensitization to dust mites and Artemisia were related to the increases in humidity and planting area of .

摘要

背景

过去十年间，中国环境变化导致的变应原致敏情况变化鲜为人知。我们旨在调查2008年至2018年间中国哮喘和/或鼻炎患者的致敏情况变化。

方法

本研究分析了2008年和2018年在中国进行的全国性调查的横断面数据。完成问卷调查后，参与者接受血清特异性IgE检测。2008年和2018年分别纳入了2322例和2798例患者。评估了中国四个地区致敏率差异的显著性。采用相关性分析确定两次调查之间致敏与气候变化及[植物名称]种植的关联。

结果

与2008年相比，2018年对螨虫的总体致敏率显著增加，在所有检测的变应原中排名最高。对花粉的致敏，尤其是[花粉名称]，在北方增加最为显著。与2008年相比，2018年所有四个地区的年平均温度、降雨量和相对湿度以及东北地区的[植物名称]覆盖率均显著增加。从2008年到2018年，[花粉名称]致敏的增加与相对湿度的增加显著相关（r = 0.54，P = 0.037）。[植物名称]致敏的增加与[植物名称]种植面积的增加显著相关（r = 0.67，P = 0.006），与降雨量的减少显著相关（r = -0.59，P = 0.021）。