Bone Marrow Metastasis from Testicular Seminoma Coexisting with Treatment-Associated Acute Myeloid Leukemia.

BACKGROUND

According to the 2017 WHO classification, therapy related myeloid neoplasms refer to therapy-related acute myeloid leukemia, therapy-related myelodysplastic syndromes, and therapy-related myelodysplastic/ myeloproliferative neoplasms, which happen as a belated occurring complication of chemotherapy and/or radiation therapy due to prior iatrogenic exposure of mutagenic agents.

RESULTS

Herein, we present a very rare case of bone marrow metastasis from testicular seminoma coexisting with treatment-associated acute myeloid leukemia.

CONCLUSIONS

This paper highlights the rare and easily misdiagnosed morphological feature of bone marrow. In these situations, clinical history, scrupulous examination of blood and bone marrow smears, immunophenotyping, and bone marrow biopsy are necessary to establish a correct diagnosis.