纤维蛋白原和纤维蛋白降解产物E抗原在肾炎性肾脏中的沉积。

Fibrinogen and FDP-E antigen deposits in nephritic kidneys.

作者信息

Nagai T, Kawai C

出版信息

Nephron. 1978;21(1):16-26. doi: 10.1159/000181367.

Abstract

Glomerular localization of fibrinogen reactive antigens (FRA) and fibrinogen degradation products reactive antigens (FDP-E) was investigated in 184 renal biopsy specimens of diseased kidneys by an immunofluorescent method. There was clear dissociation of FRA and neoantigen deposits in the glomeruli in a moderately active stage of acute glomerulonephritis, chronic glomerulonephritis and in all 5 cases of lipoid nephrosis. In lupus nephritis and membranous nephropathy there were almost coincident deposits of these antigens.

摘要

采用免疫荧光法对184例患病肾脏的肾活检标本进行了纤维蛋白原反应性抗原（FRA）和纤维蛋白原降解产物反应性抗原（FDP-E）的肾小球定位研究。在急性肾小球肾炎、慢性肾小球肾炎的中度活动期以及所有5例脂性肾病中，肾小球内FRA和新抗原沉积物明显分离。在狼疮性肾炎和膜性肾病中，这些抗原的沉积物几乎一致。