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非常严重阻塞性睡眠呼吸暂停患者在接受非框架手术治疗后,呼吸暂停低通气指数或持续时间增加的负面影响。

Negative impact of the hypopnea index or duration increase after a non-frame work surgery in patients with very severe obstructive sleep apnea.

机构信息

Department of Otolaryngology, Chang Gung Memorial Hospital, Chiayi, 61363, Taiwan, ROC.

Sleep Center, Chang Gung Memorial Hospital, Chiayi, 61363, Taiwan, ROC.

出版信息

Sci Rep. 2022 Feb 10;12(1):2251. doi: 10.1038/s41598-022-06293-6.

Abstract

A non-framework surgery could change the postoperative components of breathing disturbances and increase the frequency or duration of hypopnea in patients with very severe obstructive sleep apnea (OSA). Either an increase of hypopnea index, which increases apnea-hypopnea index (AHI), or an increase of its duration raises the concern of worsening the oxygen desaturation and so morbidity and mortality associated with OSA. It is unclear how the oxygen saturation would change in those having increased frequency or duration of hypopneas after the surgery. Here in 17 patients with AHI ≥ 60 events/h, having increased frequency or duration of hypopneas after the non-framework surgery, the results show that the surgery improved oxygen saturation by reducing obstructive-apnea index (36.1 events/h) and duration (8.6 s/event), despite it increased hypopnea index (16.8 events/h) and duration (9.8 s/event). The surgery improved the average of the mean oxyhemoglobin saturation of pulse oximetry (SpO2) by 2.8% (toward a ceiling mean of 94.3%), mean minimal SpO2 by 7.5%, and mean desaturation by 5%. The results suggest sufficient apnea reduction and shift from apnea to hypopnea may mask the negative impact of the increase of hypopnea index or duration and improve postoperative mean SpO2, minimal SpO2, and mean desaturation.

摘要

非框架手术可能会改变术后呼吸障碍的组成部分,并增加严重阻塞性睡眠呼吸暂停(OSA)患者的呼吸暂停低通气指数(hypopnea index,HI)频率或持续时间。HI 增加(即增加呼吸暂停低通气指数,apnea-hypopnea index,AHI)或其持续时间延长都会引起对血氧饱和度恶化的担忧,从而增加与 OSA 相关的发病率和死亡率。尚不清楚手术后呼吸暂停低通气频率或持续时间增加的患者,其血氧饱和度会如何变化。在 17 名 AHI≥60 次/小时的患者中,非框架手术后呼吸暂停低通气的频率或持续时间增加,结果显示,尽管呼吸暂停低通气指数(HI)和持续时间增加(分别为 16.8 次/小时和 9.8 秒/次),手术通过降低阻塞性呼吸暂停指数(36.1 次/小时)和持续时间(8.6 秒/次),改善了氧饱和度。手术将脉氧仪平均血氧饱和度(SpO2)提高了 2.8%(接近 94.3%的平均上限),平均最低 SpO2 提高了 7.5%,平均血氧饱和度下降幅度降低了 5%。结果表明,充分的呼吸暂停减少和从呼吸暂停向呼吸暂停低通气的转变可能掩盖了呼吸暂停低通气指数或持续时间增加的负面影响,并改善了术后平均 SpO2、最低 SpO2 和平均血氧饱和度下降幅度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eacc/8831531/bc717cbb47b3/41598_2022_6293_Fig1_HTML.jpg

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