Girard B, Begnaud S
Service d'ophtalmologie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75970 Paris cedex 20, France; UPMC Sorbonne université, Paris, France.
Service d'ophtalmologie, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75970 Paris cedex 20, France; UPMC Sorbonne université, Paris, France; École de l'Inserm, fondation Bettencourt-Schueller, Paris, France.
J Fr Ophtalmol. 2022 Mar;45(3):288-297. doi: 10.1016/j.jfo.2021.09.008. Epub 2022 Feb 8.
We aimed to analyze the tears of patients with Benin Essential Blepharospasm (BEB) to explore possible corneo-conjunctival mechanisms for photophobia, tear deficiency and ocular pain.
Using an observational cohort of 42 patients diagnosed with BEB, we performed Schirmer's testing, measurement of tear film pH, tear film protein electrophoresis and conjunctival impression cytology.
Schirmer's testing showed dry eye (8.4±9.7mm) with 71.3% eyes having a Schirmer's score<10mm. Surprisingly, the pH was basic (8.4±0.4) and was improved in patients receiving the standard treatment of quarterly botulinum toxin injections (8.32±0.36 for treated patients vs. 8.74±0.53 for untreated patients; P=0.045). Together, tear protein electrophoresis and conjunctival impression cytology showed conjunctival inflammation associated with BEB.
For the first time, this study emphasizes corneo-conjunctival mechanisms to explain the photophobia, dry eye and pain in Benign Essential Blepharospasm. While encouraging, complementary studies remain necessary to evaluate the effect of correcting tear film pH and inflammation on the quality of life of blepharospasm patients.
我们旨在分析贝宁特发性眼睑痉挛（BEB）患者的眼泪，以探索畏光、泪液缺乏和眼痛可能的角膜结膜机制。
我们对42例诊断为BEB的患者进行观察性队列研究，进行了泪液分泌试验、泪膜pH值测量、泪膜蛋白电泳和结膜印迹细胞学检查。
泪液分泌试验显示存在干眼（8.4±9.7mm），71.3%的眼睛泪液分泌试验评分<10mm。令人惊讶的是，pH值呈碱性（8.4±0.4），接受每季度一次肉毒杆菌毒素注射标准治疗的患者pH值有所改善（治疗患者为8.32±0.36，未治疗患者为8.74±0.53；P=0.045）。泪液蛋白电泳和结膜印迹细胞学检查共同显示BEB与结膜炎症有关。
本研究首次强调角膜结膜机制可解释良性特发性眼睑痉挛中的畏光、干眼和疼痛。虽然令人鼓舞，但仍需要补充研究来评估纠正泪膜pH值和炎症对眼睑痉挛患者生活质量的影响。
Zotero 插件