双人舞：非洲疟原虫对镰状血红蛋白的适应。
Pas-de-deux: African Plasmodium falciparum adaptations to sickle hemoglobin.
机构信息
Department of Molecular Parasitology, Institute of Biology, Humboldt University, Berlin, Germany.
Research School of Biology, The Australian National University, Canberra, Australia.
出版信息
Trends Parasitol. 2022 Apr;38(4):267-268. doi: 10.1016/j.pt.2022.01.009. Epub 2022 Feb 9.
The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.
非洲人类与恶性疟原虫之间的分子军备竞赛导致了镰状细胞病的选择，而这种疾病在总体上保护了杂合子携带者免受严重疟疾的侵害。Band 等人发现，寄生虫会反适应，并通过识别寄生虫基因组特征（称为恶性疟原虫镰状相关（Pfsa）变体）来克服疾病抗性。
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