Laboratory of Translational Immunology, Health and Sports Sciences Center, Federal University of Acre, Rio Branco 69920-900, Brazil.
Laboratory of Molecular Exercise Physiology, University Center UDF, Brasília 70390-045, Brazil.
Int J Environ Res Public Health. 2022 Feb 7;19(3):1853. doi: 10.3390/ijerph19031853.
Since the World Health Organization declared the global COVID-19 state of emergency in early 2020, several vaccine candidates have emerged to control SARS-CoV-2, and some of them have been approved and implemented in vaccination campaigns worldwide. Although clinical trials for these vaccines have been carried out using highly controlled methods with accurate immunological tests, clinical questionnaires did not include questions concerning the physical activity profile among volunteers. It has been well established that physical activity plays a pivotal role in the immune response after vaccination, led by the activation of cytokines, antibodies, and cells. This concept should have been considered when evaluating the efficacy of COVID-19 vaccine candidates, particularly in elderly and obese people. Here, we discuss data from the literature providing strong evidence regarding the importance of analyzing physical activity parameters to improve the accuracy of clinical trials on assessing the efficacy of vaccine candidates.
自 2020 年初世界卫生组织宣布全球 COVID-19 紧急状态以来，已经出现了几种候选疫苗来控制 SARS-CoV-2，其中一些已经在全球疫苗接种活动中获得批准和实施。尽管这些疫苗的临床试验采用了高度受控的方法和准确的免疫学测试，但临床问卷并未包含有关志愿者体力活动情况的问题。众所周知，体力活动在疫苗接种后的免疫反应中起着关键作用，这是由细胞因子、抗体和细胞的激活所驱动的。在评估 COVID-19 候选疫苗的疗效时，应该考虑到这一概念，特别是在老年人和肥胖人群中。在这里，我们讨论了文献中的数据，这些数据提供了有力的证据，证明分析体力活动参数对于提高临床试验评估候选疫苗疗效的准确性非常重要。
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