EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK.
Technical University of Munich, Trogerstrasse, 30, 81675, Munich, Germany.
Chem Soc Rev. 2022 Mar 21;51(6):2081-2120. doi: 10.1039/d1cs00798j.
Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and critiques the most recent advances in the field of substrate-based probes for the detection and analysis of proteolytic activity both and
蛋白酶是多种疾病的优秀生物标志物，为诊断应用提供了多种机会，并且是治疗的有价值的靶标。从化学角度来看，本综述讨论并评价了基于底物的探针在检测和分析蛋白酶活性方面的最新进展。
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