Associate Professor of Dermatology, Department of Dermatology, Malatya Education and Research Hospital, 506082Turgut Ozal University, Malatya, Turkey.
Specialist of Cardiology, Department of Cardiology, Hayat Hospital, Malatya, Turkey.
Angiology. 2022 Sep;73(8):772-780. doi: 10.1177/00033197211072599. Epub 2022 Feb 21.
Psoriasis vulgaris is associated with an increased risk of atherosclerosis. The C-Reactive Protein-to-Albumin Ratio (CAR) has received increasing attention as an independent prognostic factor for inflammatory diseases. The carotid intima-media thickness (cIMT) is a predictor of atherosclerosis. We assessed the correlation between CAR and cIMT in patients with psoriasis vulgaris. We enrolled 147 participants (72 with psoriasis vulgaris and 75 controls). Disease severity was assessed using the "Psoriasis Area Severity İndex (PASI)." Patient and control groups were similar with regard to gender, age, and body mass index (BMI). cIMT was measured in both the left and the right common carotid arteries. CAR values were higher in patients with psoriasis compared with controls (0.93 (0.06-4.32) vs 0.51 (0.10-2.99), < .001). The patients with psoriasis had a significantly greater cIMT compared with control subjects. (0.53 (0.42-0.65) vs 0.50 (0.41-0.65) mm, = .03). PASI scores were positively correlated with CAR values (r = 0.532, < .001). A positive correlation between cIMT and CAR was found in patients with psoriasis vulgaris (r = 0.463, < .001). CAR is an easily derived reproducible marker that could prove useful for assessing the inflammatory status of patients with psoriasis in clinical practice. CAR may also prove useful as a cardiovascular risk marker in these patients.
寻常型银屑病与动脉粥样硬化风险增加相关。C 反应蛋白与白蛋白比值（CAR）作为炎症性疾病的独立预后因素受到越来越多的关注。颈动脉内膜中层厚度（cIMT）是动脉粥样硬化的预测指标。我们评估了寻常型银屑病患者中 CAR 与 cIMT 之间的相关性。我们纳入了 147 名参与者（72 名寻常型银屑病患者和 75 名对照者）。疾病严重程度采用“银屑病面积严重程度指数（PASI）”进行评估。患者组和对照组在性别、年龄和体重指数（BMI）方面相似。对左右颈总动脉进行 cIMT 测量。与对照组相比，银屑病患者的 CAR 值更高（0.93（0.06-4.32）vs 0.51（0.10-2.99）， <.001）。与对照组相比，银屑病患者的 cIMT 明显更大（0.53（0.42-0.65）vs 0.50（0.41-0.65）mm， =.03）。PASI 评分与 CAR 值呈正相关（r = 0.532， <.001）。寻常型银屑病患者的 cIMT 与 CAR 之间存在正相关（r = 0.463， <.001）。CAR 是一种易于获得的可重复标志物，在临床实践中可能有助于评估银屑病患者的炎症状态。在这些患者中，CAR 也可能作为心血管风险标志物证明有用。
