Southeast Utah Health Department, Price, UT, USA.
Faculty of Medical Sciences.
Rheumatology (Oxford). 2022 Oct 6;61(10):4065-4075. doi: 10.1093/rheumatology/keac053.
To investigate which five activity interference categories out of pain, fatigue, mood, dryness and brain fog/mental fatigue scored highest in patients with primary Sjögren's syndrome (pSS) and to investigate the association between activity interference and mood and physical functioning in these patients.
The Comprehensive Pain Evaluation Questionnaire (CPEQ) assessed activity interference (actions performed in daily life that are hindered) in 149 UK pSS patients. This was modified to include four additional symptoms (fatigue, mood, dryness and brainfog/mental fatigue). Functional impairment was measured using the Hospital Anxiety and Depression Scale (HADS) and the Improved Health Assessment Questionnaire (Improved HAQ). Univariable linear regression models were estimated to investigate the association between CPEQ results and the outcome scores obtained from the HADS and Improved HAQ. Multivariable linear regression models were estimated adjusting for patient age and length of disease.
Fatigue had the biggest impact on seven activity domains: physical exercise (mean score of 3.49 out of 5 [s.d. 1.26]), performing household chores (mean 3.14 [s.d. 1.18]), gardening or shopping (mean 3.18 [s.d. 1.20]), socializing with others (mean 2.62 [s.d. 1.24]), recreation/hobbies (mean 2.88 [s.d. 1.20]), sexual relations (mean 3.00 [s.d. 1.52]), and mental efficacy (mean 2.69 [s.d. 1.17]). Regression analysis showed a positive correlation in which every point increase in an activity interference category saw the overall mood and physical functioning scores increase.
Fatigue has the largest impact on pSS patients' daily activities in this cohort. Length of disease reduced the impact of activity interference on patients' overall health score.
调查原发性干燥综合征（pSS）患者中哪五个活动干扰类别（疼痛、疲劳、情绪、干燥和脑雾/精神疲劳）得分最高，并调查这些患者的活动干扰与情绪和身体功能之间的关系。
综合疼痛评估问卷（CPEQ）评估了 149 名英国 pSS 患者的活动干扰（日常生活中受到阻碍的活动）。这被修改为包括四个附加症状（疲劳、情绪、干燥和脑雾/精神疲劳）。使用医院焦虑和抑郁量表（HADS）和改进健康评估问卷（Improved HAQ）测量功能障碍。使用单变量线性回归模型来研究 CPEQ 结果与 HADS 和改进 HAQ 获得的结果得分之间的关系。使用多变量线性回归模型调整患者年龄和疾病长度进行调整。
疲劳对七个活动领域影响最大：体育锻炼（平均得分为 5 分中的 3.49 [标准差 1.26]），做家务（平均 3.14 [标准差 1.18]），园艺或购物（平均 3.18 [标准差 1.20]），与他人交往（平均 2.62 [标准差 1.24]），娱乐/爱好（平均 2.88 [标准差 1.20]），性关系（平均 3.00 [标准差 1.52]）和精神功效（平均 2.69 [标准差 1.17]）。回归分析显示出正相关，即活动干扰类别的每个点增加都会导致整体情绪和身体功能得分增加。
在本队列中，疲劳对 pSS 患者的日常活动影响最大。疾病长度降低了活动干扰对患者整体健康评分的影响。
